{
  "abstract": "The ubiquitous myosin class-V molecular motors transport cellular cargo long distances at roughly 0.5 m/s. Plant-specific myosin class-XI motors share nearly identical structural features with myosin-V, yet display velocities from 0.25 to 70 m/s, the fastest transport motor in nature. Empirical observations suggest an inverse relationship between run length and velocity. These observations raise a central question: how can a single motor design support both highly processive \"long-hauler\" and extremely rapid \"drag-racer\" motors? We generalize a polymer-based model of force-dependent myosin-V dynamics to encompass the broader design space. The model quantitatively captures experimental data from fast myosin-XI and yields general analytical expressions for key observables. Notably, we derive a Pareto frontier that defines the trade-off between velocity and run distance, as well as the theoretical maximum velocity achievable by such motors. Our results establish the biological limits of natural and synthetic myosin-V-like motor design.",
  "abstract_shown": true,
  "affiliations": [
    "Case Western Reserve University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "J. Holmes"
    },
    {
      "affs": [
        0
      ],
      "name": "M. Hinczewski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cz0wv9mfr5527.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.25.761746",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.25.761746v1.full",
  "id": "cz0wv9mfr5527",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.25.761746v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biophysics"
    ],
    [
      "openalex",
      "1307|Microtubule and mitosis dynamics"
    ]
  ],
  "openalex": "W7223835979",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.25.761746v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cz0wv9mfr5527.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:51Z",
      "native_id": "10.64898/2026.10.25.761746",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.25.761746v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biophysics",
      "subfield": "biophysics"
    }
  ],
  "title": "Drag racers and long haulers: the design space of myosin-V-like motor proteins",
  "title_text": "Drag racers and long haulers: the design space of myosin-V-like motor proteins",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:51Z",
  "url": "https://research.draconitic.com/paper/cz0wv9mfr5527",
  "venue": "bioRxiv",
  "versions": []
}