{
  "abstract": "An efficient synthetic access to the acybolin class of inducible secondary metabolites is being reported. The approach developed features coupling between the antibiotic (-)-bactobolin A and various acybolin side chains without the need for protecting groups. The biological evaluation of synthetic acybolins in human cancer cell cultures revealed their potent antiproliferative effects.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Faculty of Science, Masaryk University, Brno625 00, Czech Republic.",
    "Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno612 00, Czech Republic.",
    "International Clinical Research Center, St. Anne's University Hospital, Brno656 91, Czech Republic."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Raju Hazra"
    },
    {
      "affs": [
        0
      ],
      "name": "Prabhakara R Tharra"
    },
    {
      "affs": [
        0
      ],
      "name": "Jovita Mary"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ondřej Naar"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Karel Souček"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jakub Švenda",
      "orcid": "0000-0001-9232-3218"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cz7fc69cv5g31.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.joc.6c01819",
  "fulltext_url": "https://europepmc.org/articles/PMC13640428",
  "id": "cz7fc69cv5g31",
  "issns": [
    "0022-3263",
    "1520-6904"
  ],
  "landing_url": "https://europepmc.org/article/MED/42916960",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7213623070",
  "pdf_url": "https://europepmc.org/articles/PMC13640428?pdf=render",
  "pmcid": "PMC13640428",
  "pmid": "42916960",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cz7fc69cv5g31.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42916960",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42916960"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity.",
  "title_text": "Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/cz7fc69cv5g31",
  "venue": "The Journal of organic chemistry",
  "versions": []
}