{
  "abstract": "Patient-reported outcomes (PROs) capture symptoms, functioning, quality of life, treatment burden and priorities directly from patients. Their integration into Molecular Tumor Board (MTB)-guided care remains limited and particularly challenging, as recommendations often involve off-label therapies, sparse evidence and complex benefit-burden trade-offs. In this perspective, we propose a four-domain framework encompassing measurement, data integration, decision support and governance to guide longitudinal monitoring and patient-centered learning.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany.",
    "Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
    "Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.",
    "Institute for Medical Informatics and Biometry, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.",
    "Charité - Universitätsmedizin Berlin, Berlin Institute of Health @ Charité, Berlin, Germany.",
    "Center for Patient-Centered Outcomes Research, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Charité Platz 1, Berlin, Germany.",
    "Department of Psychosomatic Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.",
    "Medical Center for Information and Communication Technology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.",
    "SRH Fürth University of Applied Sciences, Fürth, Germany.",
    "Data Integration Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Freiburg, Germany.",
    "Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
    "Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital Cologne, Cologne, Germany.",
    "Institute for Medical Informatics and Biometry, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany. markus.wolfien@tu-dresden.de.",
    "Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI Dresden/Leipzig), Dresden, Saxony, Germany. markus.wolfien@tu-dresden.de."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "L Gräßel"
    },
    {
      "affs": [
        0
      ],
      "name": "S Yacob"
    },
    {
      "affs": [
        2
      ],
      "name": "C Strantz"
    },
    {
      "affs": [
        3
      ],
      "name": "E Prochaska"
    },
    {
      "affs": [
        4
      ],
      "name": "T Debertshäuser"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "A A Rogge"
    },
    {
      "affs": [
        3
      ],
      "name": "S Bäcker"
    },
    {
      "affs": [
        4
      ],
      "name": "F Prasser"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "P Unberath"
    },
    {
      "affs": [
        9
      ],
      "name": "J Wehrle"
    },
    {
      "affs": [
        10
      ],
      "name": "S Jäger"
    },
    {
      "affs": [
        10
      ],
      "name": "M Boerries"
    },
    {
      "affs": [
        0
      ],
      "name": "A L Illert"
    },
    {
      "affs": [
        11
      ],
      "name": "U Lührig"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "M Wolfien",
      "orcid": "0000-0002-1887-4772"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/czhmwt77eyz6x.bib",
  "cited_by": 0,
  "doi": "10.1038/s41698-026-01719-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13722684",
  "id": "czhmwt77eyz6x",
  "issns": [
    "2397-768X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42963351",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Perspective"
    ],
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      "openalex",
      "2730|Cancer survivorship and care"
    ]
  ],
  "openalex": "W7224157440",
  "pdf_url": "https://europepmc.org/articles/PMC13722684?pdf=render",
  "pmcid": "PMC13722684",
  "pmid": "42963351",
  "published": "2026-10-29",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/czhmwt77eyz6x.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:21Z",
      "native_id": "MED:42963351",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42963351"
    },
    {
      "first_seen": "2026-11-04T12:21:27Z",
      "native_id": "PMC13722684",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41698-026-01719-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer survivorship and care",
      "subfield": "oncology"
    }
  ],
  "title": "The promise and limits of patient-reported outcomes in molecular tumor board-guided care: toward a framework for patient-centered precision oncology.",
  "title_text": "The promise and limits of patient-reported outcomes in molecular tumor board-guided care: toward a framework for patient-centered precision oncology.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:27Z",
  "url": "https://research.draconitic.com/paper/czhmwt77eyz6x",
  "venue": "NPJ precision oncology",
  "versions": []
}