{
  "abstract": "RNA modifications have emerged as critical regulators of cellular function and disease pathogenesis; however, their contribution to psoriasis remains unclear. Here, we report that N-acetyltransferase 10 (NAT10) expression is markedly elevated in the epidermis of patients with psoriasis and in imiquimod (IMQ)-induced lesions. Single-cell RNA sequencing further identifies NAT10 upregulation in hyperproliferative and basal keratinocyte subsets. Keratinocyte-specific deletion of NAT10 attenuates IMQ-induced psoriatic phenotypes in mice. Integrative profiling of RNA sequencing and N4-acetylcytidine (ac4C) immunoprecipitation sequencing reveals fatty acid synthase (FASN) as a direct downstream target of NAT10. Mechanistically, NAT10 catalyzes ac4C RNA modification to enhance the stability of FASN mRNA, thereby driving fatty acid metabolic reprogramming and promoting keratinocyte proliferation. This metabolic shift contributes to epidermal hyperplasia and inflammation in psoriasis. Notably, pharmacological inhibition of NAT10 with remodelin alleviates disease severity in vivo and in vitro . Together, these findings identify a NAT10-dependent ac4C regulatory axis that links epitranscriptomic control to metabolic dysregulation in keratinocytes and highlight NAT10 as a promising therapeutic target for psoriasis.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Translational Medicine Laboratory, Jilin Medical University, Jilin, Jilin, 132013, China",
    "Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang, 325000, China",
    "Translational Medicine Laboratory, Jilin Medical University, Jilin, Jilin, 132013, China",
    "State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China",
    "Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China",
    "Translational Medicine Laboratory, Jilin Medical University, Jilin, Jilin, 132013, China; Corresponding author.",
    "State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Weibo Tang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jingling Shen"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiaxin Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Chunhui Jiang"
    },
    {
      "affs": [
        3
      ],
      "name": "Wenya Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Mengyao Xiao"
    },
    {
      "affs": [
        3
      ],
      "name": "Jindan Dai"
    },
    {
      "affs": [
        3
      ],
      "name": "Wenjie Gao"
    },
    {
      "affs": [
        3
      ],
      "name": "Junjie Lu"
    },
    {
      "affs": [
        3
      ],
      "name": "Chunyi Hu"
    },
    {
      "affs": [
        4
      ],
      "name": "Yonghuan Song"
    },
    {
      "affs": [
        5
      ],
      "name": "Ye Xu"
    },
    {
      "affs": [
        6
      ],
      "name": "Zhongxin Zhu"
    },
    {
      "affs": [
        6
      ],
      "name": "Weitao Cong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/czt8w7p4bgdjp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jpha.2026.101590",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2095177926000456",
  "id": "czt8w7p4bgdjp",
  "issns": [
    "2095-1779",
    "2214-0883"
  ],
  "landing_url": "https://doi.org/10.1016/j.jpha.2026.101590",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7129341434",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/czt8w7p4bgdjp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:35Z",
      "native_id": "9a6225bf4c8e4967ba7548f834683413",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jpha.2026.101590"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
    }
  ],
  "title": "NAT10 aggravates psoriasis by promoting keratinocytes fatty acid synthesis via stable FASN transcription",
  "title_text": "NAT10 aggravates psoriasis by promoting keratinocytes fatty acid synthesis via stable FASN transcription",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:35Z",
  "url": "https://research.draconitic.com/paper/czt8w7p4bgdjp",
  "venue": "Journal of Pharmaceutical Analysis",
  "versions": []
}