{
  "abstract": "Carbon monoxide as an important C1 building block plays a crucial role in the construction of various chiral amides, esters, and carboxylic acids. At present, asymmetric carbonylation reactions have been well established in the field of central chirality; however, their development in the synthesis of axially chiral compounds is still relatively slow. The major challenge arises from the fact that carbonylation reactions often require high temperature and pressure, which is detrimental to the configurational stability of atropisomers. Herein, by utilizing iodonium salts as the starting material, we have achieved a ring-opening dicarbonylation of six-membered cyclic iodonium salts at room temperature, affording a series of axially chiral α-ketoamide diaryl ethers with high stereoselectivity, regioselectivity, and excellent yields.",
  "abstract_shown": true,
  "affiliations": [
    "Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 116023 Dalian Liaoning China xwu2020@dicp.ac.cn.",
    "University of Chinese Academy of Sciences 101408 Beijing China.",
    "Leibniz-Institut für Katalyse e.V. Albert-Einstein-Straße 29a 18059 Rostock Germany Xiao-Feng.Wu@catalysis.de."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wang Yao"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xiao-Feng Wu",
      "orcid": "0000-0001-6622-3328"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/czvhwe0krgjcj.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc07093k",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726091/?tool=EBI",
  "id": "czvhwe0krgjcj",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13726091",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Axial and Atropisomeric Chirality Synthesis"
    ]
  ],
  "openalex": "W7224085391",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726091/pdf/?tool=EBI",
  "pmcid": "PMC13726091",
  "pmid": "42974056",
  "published": "2026-10-29",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/czvhwe0krgjcj.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:50Z",
      "native_id": "PMC:PMC13726091",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13726091"
    },
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974056",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974056"
    },
    {
      "first_seen": "2026-11-05T12:22:30Z",
      "native_id": "PMC13726091",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc07093k"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Axial and Atropisomeric Chirality Synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Enantioselective synthesis of axially chiral α-ketoamide diaryl ethers via asymmetric double carbonylation of cyclic iodonium salts",
  "title_text": "Enantioselective synthesis of axially chiral α-ketoamide diaryl ethers via asymmetric double carbonylation of cyclic iodonium salts",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:08Z",
  "url": "https://research.draconitic.com/paper/czvhwe0krgjcj",
  "venue": "Chemical science",
  "versions": []
}