{
  "abstract": "Immune checkpoint inhibitor-associated myocarditis (ICI-myocarditis) is a rare but frequently fatal immune-related adverse event. A comprehensive understanding of the cellular and molecular determinants driving ICI-myocarditis is essential for improving diagnostic precision and developing targeted interventions. We delineate the immune landscape of ICI-myocarditis via scRNA-seq, flow cytometry, Olink proteomics, and multiplex cytokine profiling. We demonstrate that high levels of baseline ISG15⁺CD8⁺ T cells are linked to the proinflammatory features of monocytes and in vitro experiments confirm the existence of circulating ISG15⁺CD8⁺ T cells with a high potential to induce cardiomyocyte apoptosis, supporting their pathogenic potential for cardiomyocyte cytotoxicity. Notably, intercellular crosstalk between these subsets is possibly mediated via the CCL2-CCR2 axis, and its blockade attenuated ICI-induced cardiac injury in vivo. Based on the inflammatory signature in ICI-myocarditis, we develop an 8-protein custom panel with promising performance in distinguishing ICI-myocarditis from other ICIs-treated controls. JAK-STAT pathway activation promotes inflammatory programs in both ISG15⁺CD8⁺ T cells and monocytes. Furthermore, JAK-STAT inhibition ameliorates cardiac dysfunction and inflammatory infiltration while enhancing the response to anti-PD-1 therapy in mouse models. In summary, this study implicates immune-pathogenic features of ICI-myocarditis and provides a possible basis for future therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Shi-Long Zhang"
    },
    {
      "name": "Qing-Qing Cai"
    },
    {
      "name": "Jian Zhang"
    },
    {
      "name": "Yuan Liu"
    },
    {
      "name": "Hao Lu"
    },
    {
      "name": "Ye-Rui Zhang"
    },
    {
      "name": "Yu-Chen Xu"
    },
    {
      "name": "Hai-Xiang Peng"
    },
    {
      "name": "Hui-Yong Chen"
    },
    {
      "name": "Yan Wang",
      "orcid": "0000-0002-7709-0994"
    },
    {
      "name": "Lei-Lei Cheng",
      "orcid": "0000-0003-0677-7892"
    },
    {
      "name": "Jun-Bo Ge",
      "orcid": "0000-0002-9360-7332"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/czxwkk2wy5jq0.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77262-0",
  "fulltext_url": null,
  "id": "czxwkk2wy5jq0",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77262-0",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7221807459",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77262-0_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/czxwkk2wy5jq0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-77262-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77262-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Integrated multi-omics identifies distinct immune signatures with diagnostic and therapeutic implications in immune checkpoint inhibitor-induced myocarditis",
  "title_text": "Integrated multi-omics identifies distinct immune signatures with diagnostic and therapeutic implications in immune checkpoint inhibitor-induced myocarditis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/czxwkk2wy5jq0",
  "venue": "Nature Communications",
  "versions": []
}