{
  "abstract": "Asparaginase and isoaspartyl peptidase 1 (ASRGL1), also known as ALP, CRASH, hASNase3, is a protein encoded by the ASRGL1 gene located at chromosome 11q12.3 in humans. It belongs to the N-terminal nucleophilic (Ntn) hydrolase superfamily and catalyzes the hydrolysis of L-asparagine and isoaspartyl dipeptides, thereby participating in amino acid metabolism and protein homeostasis regulation. In recent years, accumulating evidence has shown that ASRGL1 is aberrantly expressed in multiple human cancers, however, its biological and prognostic implications vary substantially among tumor types and are highly tumor-context dependent. This review systematically summarizes the structure and function of ASRGL1, its expression patterns and clinical relevance, the reported functional roles and proposed mechanisms in tumorigenesis and progression, and discusses its potential as a candidate biomarker for clinical prognosis prediction.",
  "abstract_shown": true,
  "affiliations": [
    "Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China",
    "Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China",
    "Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China",
    "Institute of Cell Therapy, Soochow University, Jiangsu, Changzhou, China",
    "The First People’s Hospital of Changzhou, Changzhou, Jiangsu, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Huiping Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Zekang Li"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Renhao Geng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Lujun Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/czyzg8e3kpcb1.bib",
  "cited_by": 0,
  "doi": "10.3389/fcell.2026.1955895",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736239/",
  "id": "czyzg8e3kpcb1",
  "issns": [
    "2296-634X"
  ],
  "landing_url": "https://doi.org/10.3389/fcell.2026.1955895",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1303|Amino Acid Enzymes and Metabolism"
    ]
  ],
  "openalex": "W7223173327",
  "pdf_url": "https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1955895/pdf",
  "pmcid": "PMC13736239",
  "pmid": "42991607",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/czyzg8e3kpcb1.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:44Z",
      "native_id": "PMC13736239",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcell.2026.1955895"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1303|Amino Acid Enzymes and Metabolism",
      "subfield": "enzymology-metabolism"
    }
  ],
  "title": "Emerging roles and mechanistic insights of ASRGL1 in tumorigenesis and cancer progression",
  "title_text": "Emerging roles and mechanistic insights of ASRGL1 in tumorigenesis and cancer progression",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:44Z",
  "url": "https://research.draconitic.com/paper/czyzg8e3kpcb1",
  "venue": "Frontiers in Cell and Developmental Biology",
  "versions": []
}