{
  "abstract": "Partial-thickness thermal burns can cause substantial pain and require effective wound management to support re-epithelialization. A 30-year-old man sustained 3%-4% total body surface area partial-thickness burns of the left hand, forearm, elbow, and abdomen following a gasoline-accelerated brush fire. Despite emergency debridement, dressings, and multimodal analgesia, pain remained 6-10/10. Approximately two days after injury, an amorphous silica-based fiber (SBF) wound matrix was applied to the open wounds, while a silica-based cream (SBC) was applied to surrounding intact skin. At initial SBF/SBC treatment, patient-reported pain decreased from 7/10 to 0/10 on a 0-10 numerical rating scale (NRS), with substantial relief reported within approximately 5-10 minutes. Across 12 paired assessments, mean pain decreased from 2.46/10 before treatment to 1.17/10 afterward. Serial planimetry demonstrated progressive wound closure with complete measured closure by Day 10, with sustained epithelial coverage and minimal scarring at Day 63. Because partial-thickness burns may spontaneously re-epithelialize, and this represents a single uncontrolled case with prior and concomitant treatment, causality cannot be established. The observed temporal pain response and wound-healing trajectory support prospective controlled evaluation using standardized pain, analgesic-use, epithelialization, functional, and safety endpoints.",
  "abstract_shown": true,
  "affiliations": [
    "Research and Development, SiOxMed, Winston Salem, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Adam M Jorgensen"
    },
    {
      "affs": [
        0
      ],
      "name": "William L Hickerson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d09nw2pen3nga.bib",
  "cited_by": 1,
  "doi": "10.7759/cureus.116638",
  "fulltext_url": "https://europepmc.org/articles/PMC13685585",
  "id": "d09nw2pen3nga",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910198",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Burn Injury Management and Outcomes"
    ]
  ],
  "openalex": "W7213862443",
  "pdf_url": "https://europepmc.org/articles/PMC13685585?pdf=render",
  "pmcid": "PMC13685585",
  "pmid": "42910198",
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d09nw2pen3nga.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910198",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910198"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Burn Injury Management and Outcomes",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Rapid Pain Reduction and Wound Closure Following Treatment With an Amorphous Silica-Based Fiber Wound Matrix in Partial-Thickness Thermal Burns: A Case Report.",
  "title_text": "Rapid Pain Reduction and Wound Closure Following Treatment With an Amorphous Silica-Based Fiber Wound Matrix in Partial-Thickness Thermal Burns: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/d09nw2pen3nga",
  "venue": "Cureus",
  "versions": []
}