{
  "abstract": "Aronia melanocarpa (black chokeberry) is a polyphenol-rich berry recognized as a functional food because of its potent antioxidant properties. This study investigated the phenolic composition, antioxidant capacity, and nephroprotective effects of A. melanocarpa extract (AME) against doxorubicin (DXR)-induced renal injury. Antioxidant activity was evaluated by determining total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity. Thirty-six female Sprague–Dawley rats (180–220 g) were randomly allocated to four groups (n = 9 per group): Control, AME, DXR, and AME + DXR. AME (200 mg/kg/day) was administered orally for 21 consecutive days as a pretreatment, and acute nephrotoxicity was induced by a single intraperitoneal injection of DXR (20 mg/kg) on day 21. Samples were collected 24 h after DXR administration. Renal injury was evaluated using biochemical, histopathological, oxidative stress (OS), inflammatory, endoplasmic reticulum stress (ERS), and apoptosis-related parameters, together with TUNEL staining. HPLC–PDA analysis of 29 targeted phenolic compounds identified cya-nidin-3-galactoside (2440 µg/g FW), cyanidin-3-arabinoside (350 µg/g FW), chlorogenic acid (251.83 µg/g FW), and rutin (32.29 µg/g FW) as the major constituents. DXR markedly impaired renal function and increased oxidative stress, ERS, inflammation, and apoptosis, whereas AME pretreatment significantly attenuated these alterations. These findings are consistent with a protective effect of phenolic-rich AME against acute DXR-induced renal injury in rats, associated with attenuation of oxidative stress, inflammation, ERS, and apoptosis. Further studies are needed to confirm these findings and evaluate their potential clinical relevance.",
  "abstract_shown": true,
  "affiliations": [
    "Vocational School of Health Sciences, Karadeniz Technical University, Trabzon 61080, Türkiye",
    "Department of Medical Biochemistry, Trabzon University, Trabzon 61080, Türkiye",
    "Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye",
    "Department of Chemistry, Faculty of Science, Karadeniz Technical University, Trabzon 61080, Türkiye",
    "Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye",
    "Department of Biochemistry, Faculty of Medicine, Nakhchivan State University, Nakhchivan AZ7000, Azerbaijan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meltem Arıkan Malkoç"
    },
    {
      "affs": [
        1
      ],
      "name": "Serap Özer Yaman"
    },
    {
      "affs": [
        2
      ],
      "name": "Hüseyin Çınkılıç"
    },
    {
      "affs": [
        2
      ],
      "name": "Esin Yuluğ"
    },
    {
      "affs": [
        3
      ],
      "name": "Yakup Kara",
      "orcid": "0000-0003-3121-5023"
    },
    {
      "affs": [
        4
      ],
      "name": "Birgül Kural"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Sevgi Kolaylı",
      "orcid": "0000-0003-0437-6139"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d0a56gnxrfcwf.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31203732",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707431/?tool=EBI",
  "id": "d0a56gnxrfcwf",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/20/3732",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Chemotherapy-induced organ toxicity mitigation"
    ]
  ],
  "openalex": "W7222922770",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707431/pdf/?tool=EBI",
  "pmcid": "PMC13707431",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/d0a56gnxrfcwf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31203732",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/20/3732"
    },
    {
      "first_seen": "2026-10-30T12:21:47Z",
      "native_id": "PMC:PMC13707431",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707431"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Chemotherapy-induced organ toxicity mitigation",
      "subfield": "general"
    }
  ],
  "title": "Phenolic-Rich Aronia melanocarpa (cv. Nero) Extract Attenuates Doxorubicin-Induced Nephrotoxicity Associated with Reduced Oxidative Stress, Inflammation, and Endoplasmic Reticulum Stress",
  "title_text": "Phenolic-Rich Aronia melanocarpa (cv. Nero) Extract Attenuates Doxorubicin-Induced Nephrotoxicity Associated with Reduced Oxidative Stress, Inflammation, and Endoplasmic Reticulum Stress",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:47Z",
  "url": "https://research.draconitic.com/paper/d0a56gnxrfcwf",
  "venue": "Molecules",
  "versions": []
}