{
  "abstract": "Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischaemic causes (arterial disease and/or microvascular impairment). A retrospective, multicentre, case-control study was conducted in 2013 and 2014, including 45 systemic sclerosis patients presenting lower-limb ulcers between 2008 and 2013. The estimated prevalence of lower-limb ulcers among systemic sclerosis patients was 12.8%. Ulcers were related to venous insufficiency in 22 cases (49%), ischaemic causes in 21 (47%) and other causes in 2 (4%). Complete healing was observed in 60% of cases in a mean time of 10.3 months; 59% relapsed during a mean follow-up of 22 months. Ischaemic lower-limb ulcer outcomes were poor, with a 28.6% amputation rate. Logistic-regression multivariate analyses between ischaemic lower-limb ulcer cases and matched systemic sclerosis-controls identified past or concomitant digital ulcer and cutaneous sclerosis of the feet as independent risk factors associated with ischaemic lower-limb ulcers.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "G Bohelay"
    },
    {
      "name": "S Blaise"
    },
    {
      "name": "P Levy"
    },
    {
      "name": "A Claeys"
    },
    {
      "name": "N Baudot"
    },
    {
      "name": "J Cuny"
    },
    {
      "name": "H Maillard"
    },
    {
      "name": "F Granel-Brocard"
    },
    {
      "name": "T Boyé"
    },
    {
      "name": "C Lok"
    },
    {
      "name": "N Bénéton"
    },
    {
      "name": "C Francès"
    },
    {
      "name": "P Senet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d0eyt7t40b3sv.bib",
  "cited_by": 26,
  "doi": "10.2340/00015555-2939",
  "fulltext_url": null,
  "id": "d0eyt7t40b3sv",
  "issns": [
    "0001-5555",
    "1651-2057"
  ],
  "landing_url": "https://hal.science/hal-05790973v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.derm"
    ],
    [
      "openalex",
      "2734|Systemic Sclerosis and Related Diseases"
    ]
  ],
  "openalex": "W2797139904",
  "pdf_url": "https://medicaljournalssweden.se/actadv/article/download/2972/4634",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": "Society for Publication of Acta Dermato-Venereologica",
  "ris": "https://research.draconitic.com/paper/d0eyt7t40b3sv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05790973",
      "source": "hal",
      "url": "https://hal.science/hal-05790973v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.mhep",
      "subfield": "general"
    }
  ],
  "title": "Lower-limb Ulcers in Systemic Sclerosis: A Multicentre Retrospective Case-control Study",
  "title_text": "Lower-limb Ulcers in Systemic Sclerosis: A Multicentre Retrospective Case-control Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/d0eyt7t40b3sv",
  "venue": "Acta Dermato-Venereologica",
  "versions": []
}