{
  "abstract": "Burn injuries are challenging to treat due to wound progression and long-term scarring. Mesenchymal stem cell (MSC)–derived extracellular vesicles (EVs) have regenerative and immunomodulatory properties that may mitigate these complications. In this phase 1/2a, first-in-human, open-label study, a 48-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow MSC-derived EVs within 48 h of injury. The treated wound achieved > 99% closure within 1 week, with durable healing for over 1 year. Scar outcomes improved over 52 weeks, with Patient and Observer Scar Assessment Scale scores indicating early resolution of pain and pruritus and minimal residual scarring. No adverse events occurred. Laser Doppler imaging showed improved perfusion within 1 week, suggesting prevention of burn wound conversion. These findings support the potential of MSC-derived EVs to accelerate burn healing and reduce scar-related morbidity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Carl I Schulman"
    },
    {
      "name": "Nicholas Namias",
      "orcid": "0000-0001-7021-2250"
    },
    {
      "name": "Louis Pizano"
    },
    {
      "name": "Booker T King"
    },
    {
      "name": "Shelley Hartman"
    },
    {
      "name": "Gloria Mathews"
    },
    {
      "name": "Willistine Lenon"
    },
    {
      "name": "Heidi Kempinski"
    },
    {
      "name": "Luis Rodriguez-Menocal",
      "orcid": "0000-0002-7473-8396"
    },
    {
      "name": "Wellington Guzman"
    },
    {
      "name": "Aaron Sandoval"
    },
    {
      "name": "Evangelos V Badiavas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d0ja5tc9cmfjk.bib",
  "cited_by": 0,
  "doi": "10.1093/jbcr/irag148",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732905/",
  "id": "d0ja5tc9cmfjk",
  "issns": [
    "1559-047X",
    "1559-0488"
  ],
  "landing_url": "https://doi.org/10.1093/jbcr/irag148",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00910"
    ],
    [
      "heading",
      "Short Communications"
    ],
    [
      "openalex",
      "2746|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7203837391",
  "pdf_url": "https://academic.oup.com/jbcr/advance-article-pdf/doi/10.1093/jbcr/irag148/70725355/irag148.pdf",
  "pmcid": "PMC13732905",
  "pmid": "42623276",
  "published": "2026-08-20",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/d0ja5tc9cmfjk.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:48Z",
      "native_id": "PMC13732905",
      "source": "pmc",
      "url": "https://doi.org/10.1093/jbcr/irag148"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Wound Healing and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report",
  "title_text": "Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:48Z",
  "url": "https://research.draconitic.com/paper/d0ja5tc9cmfjk",
  "venue": "Journal of Burn Care & Research: Official Publication of the American Burn Association",
  "versions": []
}