{
  "abstract": "The management of patients with essential thrombocythemia (ET) and extreme thrombocytosis (ExT) remains plagued by several unresolved issues. Therefore, we conducted a web-based survey to better understand hematologists' clinical approaches to ExT and to compare them with responses generated by artificial intelligence (AI) programs. A total of 56 hematologists participated. Cytoreductive treatment was preferred by 41.1% of respondents at a platelet threshold of ≥ 1000 × 10⁹/L and by 83.9% at ≥ 1500 × 10⁹/L. Assessment of vWF: RCo at diagnosis was reported by 78.6% of hematologists. In the presence of cardiovascular risk factors and the absence of acquired von Willebrand disease (vWD), aspirin therapy was favored by 91.1% and 78.6% of respondents for platelet counts ≥ 1000 × 10⁹/L and ≥ 1500 × 10⁹/L, respectively. Prevention of thrombosis, prevention of bleeding, and symptom control were cited with similar frequencies as reasons for initiating cytoreductive treatment. Artificial intelligence (AI)-generated recommendations supported vWF testing, favored cytoreductive treatment, particularly at platelet counts ≥ 1500 × 10⁹/L, and generally recommended aspirin only for patients with platelet counts ≥ 1000 × 10⁹/L in the absence of acquired vWD. Overall, ExT appeared to be an important driver of treatment decisions, particularly at platelet counts ≥ 1500 × 10⁹/L. Comparisons with AI-generated recommendations revealed few differences in treatment approaches across some clinical scenarios, supporting the exploratory nature of the AI analysis.",
  "abstract_shown": true,
  "affiliations": [
    "Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Istanbul University-Cerrahpaşa, Fatih, Istanbul, Türkiye.",
    "Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Istanbul University-Cerrahpaşa, Fatih, Istanbul, Türkiye. emre.eskazan@iuc.edu.tr.",
    "Division of Hematology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye. emre.eskazan@iuc.edu.tr."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Özge Sönmez"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ahmet Emre Eşkazan",
      "orcid": "0000-0001-9568-0894"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d0xr1j6yr7ezg.bib",
  "cited_by": 0,
  "doi": "10.1007/s00277-026-07183-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13722737",
  "id": "d0xr1j6yr7ezg",
  "issns": [
    "0939-5555",
    "1432-0584"
  ],
  "landing_url": "https://europepmc.org/article/MED/42961495",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Report"
    ],
    [
      "openalex",
      "2716|Myeloproliferative Neoplasms: Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7214403946",
  "pdf_url": "https://europepmc.org/articles/PMC13722737?pdf=render",
  "pmcid": "PMC13722737",
  "pmid": "42961495",
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d0xr1j6yr7ezg.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:43Z",
      "native_id": "MED:42961495",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42961495"
    },
    {
      "first_seen": "2026-11-04T12:21:30Z",
      "native_id": "PMC13722737",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00277-026-07183-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Myeloproliferative Neoplasms: Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "When platelets reach a million: insights from hematologists.",
  "title_text": "When platelets reach a million: insights from hematologists.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:30Z",
  "url": "https://research.draconitic.com/paper/d0xr1j6yr7ezg",
  "venue": "Annals of hematology",
  "versions": []
}