{
  "abstract": "Radiotherapy for brain tumors frequently induces irreversible cognitive decline, yet the underlying mechanisms remain poorly understood. Here, we present an integrated single-cell and spatial transcriptomic atlas of radiation-induced brain injury (RIBI) in mice, spanning the acute to chronic phases. We reveal that the early-delayed phase following irradiation represents a critical window during which the blood-cerebrospinal fluid barrier (BCSFB) integrity is compromised. This disruption results from the selective depletion of a radiosensitive Tmsb4x+ epithelial subpopulation in the choroid plexus, which functions as a gatekeeper for the BCSFB. Consequently, CSF-derived macrophages excessively infiltrate the periventricular niche and engage in spatial crosstalk with interferon-responsive microglia. This dysregulated immune axis sustains chronic neuroinflammation, driving the late-stage neurodegeneration and cognitive impairment. In conclusion, our study establishes a high-resolution spatiotemporal framework and positions the BCSFB as a pivotal immune gateway and a promising therapeutic target for mitigating RIBI.",
  "abstract_shown": true,
  "affiliations": [
    "Academy of Military Medical Sciences, Beijing 100850, P.R. China",
    "Department of Neurosurgery, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, P.R. China",
    "School of Computer, Electronic and Information, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region 530004, P.R. China",
    "Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China",
    "Medical College of Guizhou University, Guiyang, Guizhou 550025, P.R. China",
    "Collaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cheng Quan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyi Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiabao Xiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiashu Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liping Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiming Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaina Hao"
    },
    {
      "affs": [
        2
      ],
      "name": "Guohang He"
    },
    {
      "affs": [
        3
      ],
      "name": "Di Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Aogang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyue Tian"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Ping"
    },
    {
      "affs": [
        0
      ],
      "name": "Siao Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qilin Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yinglong Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haitao Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiming Lu"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Gangqiao Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d106x3ykcwmpw.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103097",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710376/",
  "id": "d106x3ykcwmpw",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103097",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2808|Barrier Structure and Function Studies"
    ]
  ],
  "openalex": "W7220924874",
  "pdf_url": null,
  "pmcid": "PMC13710376",
  "pmid": "42849444",
  "published": "2026-10-08",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/d106x3ykcwmpw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:21Z",
      "native_id": "PMC13710376",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103097"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Barrier Structure and Function Studies",
      "subfield": "neurology"
    }
  ],
  "title": "A spatiotemporal atlas of radiation-induced brain injury reveals dysfunction of the blood-CSF barrier",
  "title_text": "A spatiotemporal atlas of radiation-induced brain injury reveals dysfunction of the blood-CSF barrier",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:21Z",
  "url": "https://research.draconitic.com/paper/d106x3ykcwmpw",
  "venue": "Cell Reports Medicine",
  "versions": []
}