{
  "abstract": "Objective: To identify factors associated with severe Pneumocystis jirovecii pneumonia (PJP) and in-hospital mortality and evaluate their ability to discriminate severe PJP in children without human immunodeficiency virus (HIV) infection.\n\nMethods: This single-center retrospective cohort study included 61 children with non-HIV-associated PJP admitted between February 2022 and June 2025, including 31 with non-severe and 30 with severe PJP. Univariable and multivariable Firth penalized logistic regression identified factors associated with severe PJP, and receiver operating characteristic curves assessed discrimination. A restricted Firth logistic model explored in-hospital mortality among severe cases.\n\nResults: Thirty children (49.2%) had severe PJP, and nine (14.8%) died during hospitalization; all deaths occurred in the severe group. Compared with the non-severe group, the severe group had more frequent primary immunodeficiency, fever, dyspnea, and cytomegalovirus (CMV) coinfection; higher D-dimer, lactate dehydrogenase (LDH), procalcitonin, and CT severity scores; and lower albumin, PaO2/FiO2, and CD4+/CD8+ T-cell ratios (all P<0.05). In the primary multivariable model, LDH (per 100-U/L increase: adjusted odds ratio [aOR]=1.532, 95% confidence interval [CI]: 1.061–2.374; P = 0.021) and CMV coinfection (aOR=5.164, 95% CI: 1.099–28.048; P = 0.037) were associated with severe PJP. LDH remained significant in the sensitivity analysis, whereas CMV coinfection did not. LDH discriminated severe from non-severe PJP with an area under the curve of 0.868 (95% CI: 0.776–0.960); the optimal cutoff was 423.0 U/L, with 90.0% sensitivity and 71.0% specificity. The combined model had an AUC of 0.878 (95% CI: 0.791–0.966), without significant improvement over LDH alone (P = 0.701). Among severe cases, non-survivors had more frequent malnutrition and CMV coinfection, higher LDH and procalcitonin, and lower neutrophil counts, albumin, PaO2/FiO2, and CD4+/CD8+ T-cell ratios (all P<0.05). In the exploratory mortality model, LDH (per 100-U/L increase: aOR=1.654, 95% CI: 1.080–4.271; P = 0.018) and albumin (per 1-g/L increase: aOR=0.605, 95% CI: 0.251–0.878; P = 0.004) were associated with in-hospital mortality.\n\nConclusions: Elevated LDH was consistently associated with severe PJP and showed good discrimination. CMV coinfection was associated with severe PJP only in the primary model and provided no significant incremental discrimination. Elevated LDH and decreased albumin may be associated with in-hospital mortality. Larger external cohorts are needed to validate these findings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Scientific Research, Zigong First People's Hospital, Zigong, Sichuan, China",
    "Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China",
    "Department of Pediatrics, Meishan People’s Hospital, Meishan, Sichuan, China",
    "Department of Pediatrics, Zigong First People’s Hospital, Zigong, Sichuan, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Junjie Ning"
    },
    {
      "affs": [
        2
      ],
      "name": "Dan Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhidong Yu"
    },
    {
      "affs": [
        1
      ],
      "name": "Fajuan Tang"
    },
    {
      "affs": [
        1
      ],
      "name": "Lina Qiao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d127mskcgcq5r.bib",
  "cited_by": 0,
  "doi": "10.3389/fcimb.2026.1937817",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696267/",
  "id": "d127mskcgcq5r",
  "issns": [
    "2235-2988"
  ],
  "landing_url": "https://doi.org/10.3389/fcimb.2026.1937817",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Pneumocystis jirovecii pneumonia detection and treatment"
    ]
  ],
  "openalex": "W7221469659",
  "pdf_url": "https://europepmc.org/articles/PMC13696267?pdf=render",
  "pmcid": "PMC13696267",
  "pmid": "42935836",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/d127mskcgcq5r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "PMC13696267",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcimb.2026.1937817"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42935836",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935836"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Pneumocystis jirovecii pneumonia detection and treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Factors associated with severe disease and in-hospital mortality in children with non-HIV-associated Pneumocystis jirovecii pneumonia: a single-center retrospective cohort study",
  "title_text": "Factors associated with severe disease and in-hospital mortality in children with non-HIV-associated Pneumocystis jirovecii pneumonia: a single-center retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:38Z",
  "url": "https://research.draconitic.com/paper/d127mskcgcq5r",
  "venue": "Frontiers in Cellular and Infection Microbiology",
  "versions": []
}