{
  "abstract": "Background/Aim: Although the Ki-67 labeling index (LI) is widely used as a marker of tumor proliferative activity, its prognostic utility in non-small cell lung cancer (NSCLC) remains uncertain because of heterogeneous study populations and the lack of standardized, histology-specific cutoff values.\n\nPatients and Methods: We retrospectively analyzed 1,245 patients with completely resected pathologic stage I-III NSCLC. Time-dependent receiver operating characteristic (ROC) analysis for postoperative recurrence within 5 years was used to determine Ki-67 LI cutoff values. Associations between Ki-67 LI status and recurrence-free survival (RFS) and overall survival (OS) were assessed using Kaplan-Meier analysis and multivariable Cox proportional hazards models.\n\nResults: Ki-67 LI was significantly higher in squamous cell carcinoma than in adenocarcinoma (median, 40.0% vs. 15.0%; p<0.001). Time-dependent ROC analysis yielded a cutoff value of 21.0% for the overall NSCLC cohort and histology-specific cutoff values of 13.0% for adenocarcinoma and 40.5% for squamous cell carcinoma. The corresponding 5-year area under the curves (AUCs) were 0.656 for the overall NSCLC cohort, 0.691 for adenocarcinoma, and 0.607 for squamous cell carcinoma. After multivariable adjustment, high Ki-67 LI was independently associated with poorer RFS in the overall NSCLC cohort [hazard ratio (HR)=1.40; 95% confidence interval (CI)=1.11-1.77; p=0.005], adenocarcinoma cohort (HR=1.57; 95%CI=1.15-2.16; p=0.005), and squamous cell carcinoma cohort (HR=1.82; 95%CI=1.22-2.73; p=0.004). High Ki-67 LI was also independently associated with poorer OS in the overall NSCLC and adenocarcinoma cohorts, but not in the squamous cell carcinoma cohort.\n\nConclusion: High Ki-67 LI was independently associated with an increased risk of postoperative recurrence in both adenocarcinoma and squamous cell carcinoma. Histology-specific cutoffs derived by time-dependent ROC analysis may support Ki-67-based postoperative risk stratification in resected NSCLC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan",
    "Department of Thoracic Surgery, Yokohama Rosai Hospital, Yokohama, Japan",
    "Department of Thoracic Surgery, Yokohama City University School of Medicine, Yokohama, Japan",
    "Department of Pathology, Saitama Medical University School of Medicine, Saitama, Japan",
    "Department of Pathology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan",
    "Department of Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "YOHEI KAMEDA"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "TETSUKAN WOO"
    },
    {
      "affs": [
        3
      ],
      "name": "MAI MATSUMURA"
    },
    {
      "affs": [
        4
      ],
      "name": "TOMOE SAWAZUMI"
    },
    {
      "affs": [
        5
      ],
      "name": "HIROMASA ARAI"
    },
    {
      "affs": [
        3
      ],
      "name": "KOJI OKUDELA"
    },
    {
      "affs": [
        0
      ],
      "name": "AYA SAITO"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d1gqpmj0km3xy.bib",
  "cited_by": 0,
  "doi": "10.21873/invivo.14514",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723998/",
  "id": "d1gqpmj0km3xy",
  "issns": [
    "0258-851X",
    "1791-7549"
  ],
  "landing_url": "https://doi.org/10.21873/invivo.14514",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2740|Lung Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7224411389",
  "pdf_url": "https://iv.iiarjournals.org/content/invivo/40/6/3775.full.pdf",
  "pmcid": "PMC13723998",
  "pmid": "42957226",
  "published": "2026-10-29",
  "publisher": "International Institute of Anticancer Research",
  "ris": "https://research.draconitic.com/paper/d1gqpmj0km3xy.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:32Z",
      "native_id": "PMC13723998",
      "source": "pmc",
      "url": "https://doi.org/10.21873/invivo.14514"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Lung Cancer Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Prognostic Value of Histology-specific Ki-67 Labeling Index Cutoffs in Stage I-III Non-small Cell Lung Cancer",
  "title_text": "Prognostic Value of Histology-specific Ki-67 Labeling Index Cutoffs in Stage I-III Non-small Cell Lung Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:43Z",
  "url": "https://research.draconitic.com/paper/d1gqpmj0km3xy",
  "venue": "In Vivo",
  "versions": []
}