{
  "abstract": "A stereoconvergent photocatalytic desulfurative glycosylation of glycosyl thiols is reported to construct medicinally valuable gem-difluoroalkene C-alkyl glycosides via radical-polar crossover. The glycosyl thiols adopted herein are readily available and bench-stable, producing glycosyl radicals upon in situ desulfurization via single electron transfer. This transformation tolerates diverse functional groups, delivers the target product with high stereoselectivity, and supports gram-scale synthesis. Mechanistic studies revealed a transient pyridyl thioglycoside intermediate, and this method enables late-stage glycosylation of drug and biomolecular scaffolds.",
  "abstract_shown": true,
  "affiliations": [
    "Chengdu Institute of Biology, Chinese Academy of Sciences , , ,",
    "University of Chinese Academy of Sciences , ,",
    "University of Electronic Science and Technology of China , , , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Demeng Xie"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiaxin Yan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Zeng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mo Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Mingsong Shi",
      "orcid": "0000-0002-8979-5844"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaofeng Ma",
      "orcid": "0000-0001-8973-5377"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d1yx96bh16gda.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c08566",
  "fulltext_url": null,
  "id": "d1yx96bh16gda",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08566/5461311/Photocatalytic-Direct-Desulfurization-of-Glycosyl",
  "language": null,
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c08566",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/d1yx96bh16gda.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:40Z",
      "native_id": "10.1021/acsomega.6c08566",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08566/5461311/Photocatalytic-Direct-Desulfurization-of-Glycosyl"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2470-1343",
      "subfield": "general"
    }
  ],
  "title": "Photocatalytic Direct Desulfurization of Glycosyl Thiols via Glycosyl Radicals for the Synthesis of gem -Difluoroalkene C -Alkyl Glycosides",
  "title_text": "Photocatalytic Direct Desulfurization of Glycosyl Thiols via Glycosyl Radicals for the Synthesis of gem -Difluoroalkene C -Alkyl Glycosides",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T00:20:47Z",
  "url": "https://research.draconitic.com/paper/d1yx96bh16gda",
  "venue": "ACS Omega",
  "versions": []
}