{
  "abstract": "We performed this systematic review and meta-analysis to assess the efficacy and safety of anticoagulation therapy versus no anticoagulation in pediatric patients with cerebral sinovenous thrombosis (CSVT). Eligible studies included pediatric patients with CSVT that compared anticoagulation to no anticoagulation and reported on at least one relevant outcome (mortality, neurological deficit, thrombus resolution, recurrence, and bleeding). Meta-analysis reported risk ratios (RR) or differences (RD) (95% CIs) and absolute effects per 1000 patients. Risk of bias was assessed using ROBINS-I, and the certainty of evidence was evaluated with GRADE. After removing duplicates, we screened 8925 records independently and in duplicate, from which 12 nonrandomized studies of intervention were included. Compared with no anticoagulation, anticoagulation may be associated with lower risk of overall mortality RR 0.14 (0.05-0.39) (4 studies, n = 448), lower risk of neurological deficits RD −0.13 (−0.39 to 0.13) (6 studies, n = 462), and higher rates of complete and partial resolution RR 1.25 (0.94-1.66) (7 studies, n = 150). Recurrence RD 0 (−0.11 to 0.11) (2 studies, n = 56) and bleeding RD 0.03 (−0.09 to 0.15) (5 studies, n = 95) may be comparable between anticoagulation versus no anticoagulation. We judged outcomes to be very low to low certainty of evidence due to risk of bias, concerns from confounding, and imprecision from small sample sizes. To conclude, we show in this systematic review that anticoagulation therapy in pediatric patients with CSVT may be associated with better outcomes (reduced mortality, neurological deficits, and higher rate of thrombus resolution) with little to no effect on bleeding and recurrence.",
  "abstract_shown": true,
  "affiliations": [
    "Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA",
    "Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; Department of Internal Medicine, Saint Louis University School of Medicine, St louis, MO, USA",
    "Department of Pediatrics, Division of Hematology, Johns Hopkins All Children’s Hospital, St. Petersburg, FL, USA",
    "Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA",
    "Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA",
    "University of Kansas School of Medicine, Kansas City, KS, USA",
    "Department of Emergency Medicine-Critical Care Medicine, Emory University, Atlanta, GA, USA",
    "Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA",
    "Department of Haematology, The Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, Tyne & Wear, United Kingdom",
    "Department of Hematology, Versiti Medical Sciences Institute, Wauwatosa, WI, USA",
    "Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada",
    "Department of Pediatrics, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada",
    "Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA",
    "Department of Pediatrics, Division of Hematology/Oncology, University of California, San Diego, Rady Children’s Hospital, San Diego, CA, USA",
    "Department of Nursing, University of Melbourne, Royal Children's Hospital, Melbourne, Australia",
    "Department of Pediatrics, Nationwide Children’s Hospital and The Ohio State University College of Medicine, Columbus, OH, USA",
    "Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA",
    "Department of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA",
    "Department of Paediatrics, Medical University of Vienna, Vienna, Austria",
    "Division of Hematology-Oncology, Department of Pediatrics, CHU de Québec, Centre Mère-Enfant Soleil, Québec, QC, Canada",
    "Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA",
    "Department of Pediatric Hematology Oncology, University of Nebraska Medical Center, Omaha, NE",
    "Department of Pediatrics, Section of Hematology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA",
    "Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA",
    "Department of Pediatrics, University of Cincinnati College of Medicine, Cancer and Blood Disease Institute Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA",
    "Department of Pediatric Hematology, Erasmus Medical Center Sophia Children's Hospital, Rotterdam, Netherlands",
    "Department of Pediatrics, Division of Hematology-Oncology, Louisiana State University Health Sciences Center and Manning Family Children’s, New Orleans, LA, USA",
    "Hudson College of Public Health, Department of Biostatistics and Epidemiology, University of Oklahoma Health, Oklahoma City, OK, USA",
    "Department of Pediatrics, Division of Hematology/Oncology, McMaster University, Hamilton, ON, Canada",
    "Department of Pediatrics, University of Alabama at Birmingham Heersink School of Medicine and Children’s of Alabama, Birmingham, AL, USA",
    "Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA",
    "Department of Pediatrics, Division of Hematology-Oncology, UT Southwestern Medical Center, Dallas, TX, USA",
    "Departments of Paediatrics and Haematology, Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Victoria, Australia",
    "Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA"
  ],
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  "author_total": 39,
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        0
      ],
      "name": "Muayad Azzam"
    },
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      "name": "Hassan Kawtharany"
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        2
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      "name": "Marisol Betensky"
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        0
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      "name": "Aseel Alkhader"
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      "name": "Qais Hamarsha"
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      "name": "Hadi Khaled Abou Zeid"
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      "name": "Rukhmi Bhat"
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      "name": "Tina Biss"
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      "name": "Brian R. Branchford"
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      "name": "Leonardo R. Brandão"
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      "name": "Anthony K.C. Chan"
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      "name": "E. Vincent S. Faustino"
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      "name": "Julie Jaffray"
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      "name": "Sophie Jones"
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      ],
      "name": "Bryce A. Kerlin"
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        16
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      "name": "Nicole Kucine"
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      "name": "Riten Kumar"
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      "name": "Christoph Male"
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      "name": "Marie-Claude Pelland-Marcotte"
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      "name": "Leslie Raffini"
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      "name": "Chittalsinh M. Raulji"
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      "name": "Sarah E. Sartain"
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      "name": "Clifford M. Takemoto"
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      "name": "Maria C. Velez"
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      "name": "Sara K. Vesely"
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      "name": "Ayesha Zia"
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        32
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      "name": "Paul Monagle"
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        33
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      "name": "Reem A. Mustafa"
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  "bibtex": "https://research.draconitic.com/paper/d2j5trctjkjzp.bib",
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  "doi": "10.1016/j.rpth.2026.106905",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2475037926035636",
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  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
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      "RC633-647.5"
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      "openalex",
      "2728|Cerebral Venous Sinus Thrombosis"
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  "openalex": "W7203483057",
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  "published": "2026-08-01",
  "publisher": "Elsevier",
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  "title": "Efficacy and safety of anticoagulation for pediatric cerebral sinovenous thrombosis: systematic review and meta-analysis",
  "title_text": "Efficacy and safety of anticoagulation for pediatric cerebral sinovenous thrombosis: systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:30Z",
  "url": "https://research.draconitic.com/paper/d2j5trctjkjzp",
  "venue": "Research and Practice in Thrombosis and Haemostasis",
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