{
  "abstract": "Septins are cytoskeletal GTP-binding proteins that organize microtubules and scaffold polarity complexes. Here, we uncover a polybasic (PB)-domain-dependent mechanism by which septin 9 controls apico-basal polarity in epithelial cells. Septin 9 regulates centrosome positioning and the asymmetric distribution of acetylated microtubules, which are required for ciliogenesis and lumen formation. Knockdown of septin 9 or deletion of its PB domains disrupts centrosome asymmetry, induces a symmetric distribution of acetylated tubulin, and impairs cilia formation, leading to polarity inversion. These defects are associated with increased expression of the microtubule deacetylase HDAC6. Importantly, inhibition of TGF-β signaling or selective HDAC6 inhibition with tubacin restores microtubule acetylation and rescues apico-basal polarity. Together, our findings identify septin 9 as a cytoskeletal integrator that links centrosome positioning and microtubule acetylation to epithelial morphogenesis through the TGF-β/HDAC6 pathway.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Mohyeddine Omrane"
    },
    {
      "name": "Nassima Benzoubir"
    },
    {
      "name": "Didier Samuel"
    },
    {
      "name": "Ama Gassama-Diagne"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d3qmpnz2p3643.bib",
  "cited_by": 0,
  "doi": "10.1002/1873-3468.70363",
  "fulltext_url": null,
  "id": "d3qmpnz2p3643",
  "issns": [
    "0014-5793",
    "1873-3468"
  ],
  "landing_url": "https://hal.science/hal-05840912v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1307|Microtubule and mitosis dynamics"
    ]
  ],
  "openalex": "W7162448521",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-26",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/d3qmpnz2p3643.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "hal-05840912",
      "source": "hal",
      "url": "https://hal.science/hal-05840912v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Microtubule and mitosis dynamics",
      "subfield": "cell-biology"
    }
  ],
  "title": "Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity",
  "title_text": "Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/d3qmpnz2p3643",
  "venue": "FEBS Letters",
  "versions": []
}