{
  "abstract": "Purpose\n\nIodinated contrast media (ICM) are widely used in diagnostic imaging, but may trigger immediate hypersensitivity reactions, including anaphylaxis. Although human leukocyte antigen (HLA) associations have been proposed, genome-wide evidence remains limited. To identify genetic risk variants associated with ICM-induced anaphylaxis and evaluate their clinical utility.Methods\n\nWe conducted a genome-wide association study (GWAS) in 91 Korean patients with confirmed ICM-induced anaphylaxis (discovery, n = 67; replication, n = 24) and 1,565 controls. Genotyping used a Korean-specific single nucleotide polymorphism (SNP) array. Significant variants were replicated. HLA alleles were imputed in the combined dataset. Linkage disequilibrium (LD) among significant loci was analyzed. Cumulative genetic burden was assessed by summing risk alleles per individual. A Least Absolute Shrinkage and Selection Operator-based prediction model incorporated genetic and clinical variables.Results\n\nNineteen SNPs reached genome-wide significance and were replicated, including rs2229629 in HK2 (odds ratio, 5.02; P = 9.6 × 10⁻²³), suggesting altered glycolysis. Additional variants were found near GABBR1, ZNF391, ATAT1, and HLA genes. Imputed HLA-DRB1*15:02 was significantly enriched in patients (41.8% vs. 5.9%, P = 5.21 × 10⁻¹⁷). LD analysis showed haplotypic clustering within HLA and non-HLA loci. A gene dosage effect was observed. The combined genetic-clinical model showed the highest predictive performance (area under the curve [AUC] = 0.888), exceeding genetic (AUC = 0.800) and clinical (AUC = 0.835) models.Conclusions\n\nThis first GWAS of ICM-induced anaphylaxis identifies susceptibility loci across metabolic, immune, and neuroimmune pathways. HK2 was most strongly associated, and HLA-DRB1*15:02 was robustly replicated.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.",
    "Allergy and Clinical Immunology Research Center, Hallym University College of Medicine, Chuncheon, Korea.",
    "JS Link, Inc., Seoul, Korea.",
    "Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.",
    "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.",
    "Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.",
    "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.",
    "Institute of Allergy and Clinical Immunology, Medical Research Center, Seoul National University, Seoul, Korea.",
    "AgingLab Inc., Ulsan, Korea.",
    "Korean Genomics Center, Ulsan National Institute of Science and Technology, Ulsan, Korea.",
    "Institute of Allergy and Clinical Immunology, Medical Research Center, Seoul National University, Seoul, Korea. helenmed@snu.ac.kr.",
    "Institute of Allergy and Clinical Immunology, Medical Research Center, Seoul National University, Seoul, Korea. addchang@snu.ac.kr."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Soo Jie Chung",
      "orcid": "0000-0002-7717-1188"
    },
    {
      "affs": [
        2
      ],
      "name": "Eunsoon Shin",
      "orcid": "0000-0001-8408-2696"
    },
    {
      "affs": [
        2
      ],
      "name": "Yong-Seok Kim",
      "orcid": "0000-0001-8795-236X"
    },
    {
      "affs": [
        3
      ],
      "name": "So-Hee Lee",
      "orcid": "0000-0003-0932-7256"
    },
    {
      "affs": [
        3
      ],
      "name": "Sun-Sin Kim",
      "orcid": "0000-0002-0664-3256"
    },
    {
      "affs": [
        4
      ],
      "name": "Sun Young Paik",
      "orcid": "0000-0002-9411-7714"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Heung-Woo Park",
      "orcid": "0000-0002-6970-3228"
    },
    {
      "affs": [
        4,
        6,
        7
      ],
      "name": "Sae-Hoon Kim",
      "orcid": "0000-0002-2572-5302"
    },
    {
      "affs": [
        8
      ],
      "name": "Sungwon Jeon",
      "orcid": "0000-0002-2729-9087"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Jong Bhak",
      "orcid": "0000-0002-4228-1299"
    },
    {
      "affs": [
        5,
        6,
        10
      ],
      "name": "Hye-Ryun Kang",
      "orcid": "0000-0002-2317-4201"
    },
    {
      "affs": [
        4,
        6,
        11
      ],
      "name": "Yoon-Seok Chang",
      "orcid": "0000-0003-3157-0447"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d4328p46jx5pv.bib",
  "cited_by": 0,
  "doi": "10.4168/aair.2026.18.5.776",
  "fulltext_url": "https://europepmc.org/articles/PMC13655407",
  "id": "d4328p46jx5pv",
  "issns": [
    "2092-7355",
    "2092-7363"
  ],
  "landing_url": "https://europepmc.org/article/MED/42845231",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Drug-Induced Adverse Reactions"
    ]
  ],
  "openalex": "W7214774214",
  "pdf_url": "https://europepmc.org/articles/PMC13655407?pdf=render",
  "pmcid": "PMC13655407",
  "pmid": "42845231",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d4328p46jx5pv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42845231",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42845231"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Drug-Induced Adverse Reactions",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Genome-Wide Risk Assessment and Clinical Prediction of Iodinated Contrast Media-Induced Anaphylaxis.",
  "title_text": "Genome-Wide Risk Assessment and Clinical Prediction of Iodinated Contrast Media-Induced Anaphylaxis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/d4328p46jx5pv",
  "venue": "Allergy, asthma & immunology research",
  "versions": []
}