{
  "abstract": "Under real-world conditions, the German cockroach Blattella germanica is frequently exposed to sublethal insecticide concentrations, yet the long-term consequences for population dynamics remain poorly understood. Here, we investigated the intergenerational effects of sublethal chlorpyrifos exposure in this urban pest. Newly emerged adults were treated with LD10 or LD30, and fitness-related traits and molecular responses were evaluated in the F0 and F1 generations. Sublethal exposure reduced fecundity and longevity in the F0 generation. Parental exposure also induced intergenerational effects in the F1 generation, including prolonged development, reduced survival, altered reproductive timing, and a decreased net reproductive rate. Population projection analysis indicated that LD10 suppressed long-term population growth. Chlorpyrifos further induced dose-dependent and intergenerational changes in detoxification-related genes, particularly BgCYP6ER1 and BgCYP6J1. In addition, mtDNA copy number increased under LD30, whereas BgCytb transcription was downregulated in the F1 generation, suggesting mitochondrial dysregulation under sublethal stress. These findings demonstrate that sublethal chlorpyrifos exposure can induce intergenerational effects on fitness-related traits and molecular responses. and highlight potential implications for pesticide risk assessment and resistance management.",
  "abstract_shown": true,
  "affiliations": [
    "Chongqing Key Laboratory of Vector Control and Utilization, Institute of Entomology and Molecular Biology, Chongqing Normal University, Chongqing, China"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiang-Ling Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Zi-Han Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun Tao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Shu-Lin He"
    },
    {
      "affs": [
        0
      ],
      "name": "Fei Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Cao Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d46kq7q68w267.bib",
  "cited_by": 0,
  "doi": "10.1016/j.cris.2026.100136",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734963/",
  "id": "d46kq7q68w267",
  "issns": [
    "2666-5158"
  ],
  "landing_url": "https://doi.org/10.1016/j.cris.2026.100136",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Communication"
    ],
    [
      "openalex",
      "1312|Insect Resistance and Genetics"
    ]
  ],
  "openalex": "W7223381264",
  "pdf_url": null,
  "pmcid": "PMC13734963",
  "pmid": "42990631",
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/d46kq7q68w267.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:45Z",
      "native_id": "PMC13734963",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.cris.2026.100136"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Insect Resistance and Genetics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Sublethal chlorpyrifos exposure induces intergenerational fitness costs and mitochondrial alterations in Blattella germanica",
  "title_text": "Sublethal chlorpyrifos exposure induces intergenerational fitness costs and mitochondrial alterations in Blattella germanica",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:45Z",
  "url": "https://research.draconitic.com/paper/d46kq7q68w267",
  "venue": "Current Research in Insect Science",
  "versions": []
}