{
  "abstract": "People with severe obesity show marked heterogeneity in cardiometabolic risk, classified as metabolically healthy (MHO) or unhealthy obesity (MUO). In this exploratory pilot study, we performed genome-wide serum microRNA (miRNA) profiling using Agilent SurePrint G3 microarrays (8 × 60 K; 2,549 probes) before and three months after sleeve gastrectomy (SG) in eight people with severe obesity (MHO n = 4; MUO n = 4) classified per Japanese national criteria. Despite comparable body mass index and visceral fat area, people with MUO had significantly higher HOMA-IR, fasting glucose, fasting insulin, HbA1c, and AST at baseline (all p = 0.029). Pre-operative miR-5100 expression correlated with baseline HOMA-IR (ρ = 0.805, p = 0.016) and predicted post-operative HOMA-IR reduction (ρ=−0.878, p = 0.004). Pre-operative miR-5585-3p predicted post-operative CRP reduction (ρ=−0.854, p = 0.007). Set analysis identified ten miRNAs, including miR-22-3p, detected in all MUO but no MHO participants. Welch’s t-test identified 23 miRNAs significantly altered post-operatively in MUO versus 8 in MHO. miR-8069 was consistently down-regulated after SG across all participants (Wilcoxon p = 0.016). Consistency across complementary analytical methods supports reliability despite the small sample. These preliminary findings suggest that pre-operative serum miRNA profiles may differ between MHO and MUO phenotypes and may predict metabolic responsiveness to bariatric surgery, and warrant validation in larger independent cohorts.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Metabolic and Bariatric Surgery, Ohama Daiichi Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Susumu Inamine"
    },
    {
      "affs": [
        0
      ],
      "name": "Yasunori Uesato"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d4fy3e1pmscbr.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-69499-y",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-69499-y",
  "id": "d4fy3e1pmscbr",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-69499-y",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
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      "lcc",
      "R"
    ],
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      "openalex",
      "2746|Bariatric Surgery and Outcomes"
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  "pdf_url": "https://www.nature.com/articles/s41598-026-69499-y_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/d4fy3e1pmscbr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:56Z",
      "native_id": "20166ca43eb34661a55e6abbbc036ff9",
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      "url": "https://doi.org/10.1038/s41598-026-69499-y"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Bariatric Surgery and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Pre-operative serum microRNA profiles differ between metabolic phenotypes and predict metabolic response to sleeve gastrectomy in severe obesity",
  "title_text": "Pre-operative serum microRNA profiles differ between metabolic phenotypes and predict metabolic response to sleeve gastrectomy in severe obesity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:56Z",
  "url": "https://research.draconitic.com/paper/d4fy3e1pmscbr",
  "venue": "Scientific Reports",
  "versions": []
}