{
  "abstract": "Objective: To describe the recorded prevalence and incidence of HS across pathologically related diseases within the spondyloarthritis (SpA) family, namely psoriatic arthritis (PsA), psoriasis, axial spondyloarthritis (axSpA), uveitis, Crohn’s disease, ulcerative colitis, and, for context, rheumatoid arthritis (RA).\n\nMethods: We conducted a retrospective cohort study using electronic health records data between June 2006 and June 2026. ICD codes were used to define populations of SpA-related diseases and RA. We estimated recorded baseline prevalence and crude incidence of HS, then separately performed 1:1 propensity-score matched comparisons of each disease with healthcare controls, matching for age, sex, BMI and comorbidities.\n\nResults: The disease populations ranged from 55,407 to 429,647 individuals. Recorded HS prevalence was highest in psoriasis (0.65%), PsA (0.52%) and Crohn’s disease (0.47%). Crude incidence was highest in Crohn’s (187.4 per 100,000 person-years) and PsA (134.1 per 100,000 person-years). After matching, incidence was higher than in controls for PsA (incidence rate ratio [IRR] 1.63, 95% CI 1.41-1.88), Crohn’s disease (2.02, 1.85-2.20), and ulcerative colitis (1.17, 1.04-1.32). Incidence was lower than controls in axSpA and RA.\n\nConclusions: This study highlights a significant epidemiological association between HS and PsA and Crohn’s disease. Clinicians providing care to these patient groups should consider enquiring about HS symptoms, although overall incidence rates are low. Further research is needed into the shared pathophysiology of HS and psoriatic disease.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom.",
    "Department of Rheumatology, Manchester University NHS Foundation Trust, Manchester, United Kingdom.",
    "Department of Medicine, University Hospital Aintree, University Hospitals of Liverpool Group, Liverpool, United Kingdom.",
    "Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.",
    "Department of General Surgery (Coloproctology), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.",
    "Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.",
    "Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.",
    "Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.",
    "Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Sizheng Steven Zhao",
      "orcid": "0000-0002-3558-7353"
    },
    {
      "affs": [
        3
      ],
      "name": "Qingfan Yang"
    },
    {
      "affs": [
        4,
        5,
        6
      ],
      "name": "Zhimin Liu"
    },
    {
      "affs": [
        7
      ],
      "name": "Zenas Yiu",
      "orcid": "0000-0002-1831-074X"
    },
    {
      "affs": [
        2,
        8
      ],
      "name": "Uazman Alam"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d4gp8f89hzbxf.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1945638",
  "fulltext_url": "https://europepmc.org/articles/PMC13710283",
  "id": "d4gp8f89hzbxf",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1945638/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Research Report"
    ],
    [
      "openalex",
      "2708|Hidradenitis Suppurativa and Treatments"
    ]
  ],
  "openalex": "W7212101591",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1945638/pdf",
  "pmcid": "PMC13710283",
  "pmid": "42948030",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/d4gp8f89hzbxf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1945638",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1945638/full"
    },
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948030",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948030"
    },
    {
      "first_seen": "2026-10-31T12:21:17Z",
      "native_id": "PMC13710283",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1945638"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Incidence and prevalence of hidradenitis suppurativa across spondyloarthritis-related diseases: cohort study using electronic health records",
  "title_text": "Incidence and prevalence of hidradenitis suppurativa across spondyloarthritis-related diseases: cohort study using electronic health records",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:17Z",
  "url": "https://research.draconitic.com/paper/d4gp8f89hzbxf",
  "venue": "Frontiers in Immunology",
  "versions": []
}