{
  "abstract": "Background: Stroke remains a serious complication after transcatheter aortic valve replacement (TAVR), even with contemporary devices. The objective of the study was to evaluate the incidence, predictors, and prognosis of in-hospital stroke in patients undergoing TAVR with contemporary valve platforms. Methods: We analyzed 5123 patients from the multicenter OCEAN-TAVI registry who underwent TAVR with SAPIEN 3 Ultra RESILIA, Evolut FX, or Navitor between May 2022 and December 2024. Stroke incidence across valve types was compared using inverse probability of treatment weighting (IPTW). Predictors were assessed using multivariable Firth penalized logistic regression. Results: In-hospital stroke occurred in 2.5% of patients. After IPTW adjustment, stroke incidence differed among valve types: 1.7% of patients treated with SAPIEN 3 Ultra RESILIA (S3UR), 4.5% with Evolut FX, and 2.4% with Navitor ( p = 0.044). Disabling stroke was more frequent with Evolut FX (2.5%) compared with S3UR (0.4%) and Navitor (0.7%; p < 0.001). Self-expanding valve use (adjusted odds ratio [aOR] 2.64, 95% CI 1.67–4.16 for Evolut FX; aOR 2.37, 95% CI 1.35–4.18 for Navitor; both vs. S3UR), prior stroke (aOR 1.83, 95% CI 1.19–2.73), reduced renal function, and nontransfemoral access (aOR 2.11, 95% CI 1.29–3.45) were independently associated with in-hospital stroke. One-year survival was significantly lower among patients with stroke than among those without stroke (73.0% vs. 90.3%; p < 0.001). Conclusions: In-hospital stroke remains an important complication after contemporary TAVR and is associated with worse clinical outcomes. Differences in stroke incidence across valve types were observed, highlighting the need for improved risk assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan; Address correspondence to: Yusuke Watanabe, MD, Department of Cardiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan.",
    "Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan; Department of Cardiology, Nagoya Heart Center, Nagoya, Japan; Department of Cardiology, Gifu Heart Center, Gifu, Japan",
    "Department of Cardiology, IMS Tokyo Katsushika General Hospital, Tokyo, Japan",
    "Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan",
    "Department of Cardiology, Nagoya Heart Center, Nagoya, Japan",
    "Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan",
    "Department of Cardiology, New Tokyo Hospital, Matsudo, Japan",
    "Department of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan",
    "Department of Cardiology, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan",
    "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan",
    "Department of Cardiology, Gifu Heart Center, Gifu, Japan",
    "Department of Cardiology, Saiseikai Utsunomiya Hospital, Tochigi, Japan",
    "Department of Cardiology, Kindai University, Osaka, Japan",
    "Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan",
    "Department of Cardiology, St. Marianna University School of Medicine, Kawasaki, Japan",
    "Department of Cardiology, Tsukuba Medical Center Hospital, Tsukuba, Japan",
    "Department of Cardiology, Toyama University Hospital, Toyama, Japan",
    "Department of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto, Japan",
    "Department of Cardiology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan",
    "Department of Cardiology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan",
    "Department of Cardiology, Sapporo Heart Center, Sapporo Cardiovascular Clinic, Sapporo, Japan",
    "Department of Cardiology, Kurashiki Central Hospital, Okayama, Japan",
    "Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan; Center for Clinical Research, Nippon Medical School Hospital, Tokyo, Japan",
    "Department of Cardiology, Keio University School of Medicine, Tokyo, Japan; Department of Medicine II, Kansai Medical University, Osaka, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 32,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yusuke Watanabe, MD"
    },
    {
      "affs": [
        1
      ],
      "name": "Masanori Yamamoto, MD"
    },
    {
      "affs": [
        2
      ],
      "name": "Hirofumi Hioki, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Masafumi Saito, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Jo Omiya, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Kento Kito, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Yasuyuki Tsuchida, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Yosei Iseki, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Masataka Arakawa, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Mizuki Miura, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Akihisa Kataoka, MD"
    },
    {
      "affs": [
        4
      ],
      "name": "Takahiro Tokuda, MD"
    },
    {
      "affs": [
        5
      ],
      "name": "Shinichi Shirai, MD"
    },
    {
      "affs": [
        5
      ],
      "name": "Kenichi Ishizu, MD"
    },
    {
      "affs": [
        6
      ],
      "name": "Toru Naganuma, MD"
    },
    {
      "affs": [
        7
      ],
      "name": "Futoshi Yamanaka, MD"
    },
    {
      "affs": [
        8
      ],
      "name": "Masahiko Noguchi, MD"
    },
    {
      "affs": [
        9
      ],
      "name": "Yohei Ohno, MD"
    },
    {
      "affs": [
        10
      ],
      "name": "Tetsuro Shimura, MD"
    },
    {
      "affs": [
        11
      ],
      "name": "Fumiaki Yashima, MD"
    },
    {
      "affs": [
        12
      ],
      "name": "Gaku Nakazawa, MD"
    },
    {
      "affs": [
        13
      ],
      "name": "Masahiko Asami, MD"
    },
    {
      "affs": [
        14
      ],
      "name": "Masaki Izumo, MD"
    },
    {
      "affs": [
        15
      ],
      "name": "Hidetaka Nishina, MD"
    },
    {
      "affs": [
        16
      ],
      "name": "Hiroshi Ueno, MD"
    },
    {
      "affs": [
        17
      ],
      "name": "Hiroto Suzuyama, MD"
    },
    {
      "affs": [
        18
      ],
      "name": "Kazumasa Yamasaki, MD"
    },
    {
      "affs": [
        19
      ],
      "name": "Kenji Nishioka, MD"
    },
    {
      "affs": [
        20
      ],
      "name": "Daisuke Hachinohe, MD"
    },
    {
      "affs": [
        21
      ],
      "name": "Yasushi Fuku, MD"
    },
    {
      "affs": [
        22
      ],
      "name": "Toshiaki Otsuka, MD"
    },
    {
      "affs": [
        23
      ],
      "name": "Kentaro Hayashida, MD"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d4nxnw1b81a5p.bib",
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  "doi": "10.1016/j.shj.2026.101099",
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  "language": "en",
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  "licence_label": "CC BY",
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  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "heading",
      "Original Research"
    ],
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      "lcc",
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  "pdf_url": "https://europepmc.org/articles/PMC13711442?pdf=render",
  "pmcid": "PMC13711442",
  "pmid": "42948592",
  "published": "2026-07-22",
  "publisher": "Elsevier",
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  ],
  "title": "Stroke After Transcatheter Aortic Valve Replacement With Contemporary Valves: Insights From the OCEAN-TAVI Registry",
  "title_text": "Stroke After Transcatheter Aortic Valve Replacement With Contemporary Valves: Insights From the OCEAN-TAVI Registry",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:13Z",
  "url": "https://research.draconitic.com/paper/d4nxnw1b81a5p",
  "venue": "Structural Heart",
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