{
  "abstract": "Of the two lineages of lentivirus that endemically infect chimpanzees, only one has served as a source of infections in hu-mans. Using HIV-CRISPR screening, we identify factors that limit the replication of lentivirus from Eastern chimpanzees. We find that CypA restricts nonzoonotic Eastern chimpanzee lentivirus due to a unique feature encoded in capsid. The ability of CypA to restrict lentivirus replication is surprising given that CypA is a host factor exploited by HIV to promote its replica-tion. The selective ability of CypA to restrict this virus provides a molecular explanation as to why lentivirus from Eastern Chimpanzees has never been observed to infect humans. Our work has important implications for understanding the origins of HIV-1 and the potential for novel zoonosis of primate lentiviruses.",
  "abstract_shown": true,
  "affiliations": [
    "UC Berkeley"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "M. J. Young"
    },
    {
      "name": "F. Cotera"
    },
    {
      "name": "C. C. C. Gill"
    },
    {
      "name": "J. A. Lewis"
    },
    {
      "name": "F. G. Whitby"
    },
    {
      "name": "A. Abdellatif"
    },
    {
      "name": "J. L. Rocha"
    },
    {
      "name": "M. Singer"
    },
    {
      "name": "M. A. Nalls"
    },
    {
      "name": "F. Faghri"
    },
    {
      "name": "P. H. Sudmant"
    },
    {
      "name": "O. Pornillos"
    },
    {
      "affs": [
        0
      ],
      "name": "M. Ohainle"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d4vwy4fvzfx7z.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.08.747897",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.747897v1.full",
  "id": "d4vwy4fvzfx7z",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.747897v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ],
    [
      "openalex",
      "2406|HIV Research and Treatment"
    ]
  ],
  "openalex": "W7212113376",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.747897v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d4vwy4fvzfx7z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:42Z",
      "native_id": "10.64898/2026.09.08.747897",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.747897v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "CypA is a molecular barrier to HIV emergence from Eastern chimpanzees",
  "title_text": "CypA is a molecular barrier to HIV emergence from Eastern chimpanzees",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:42Z",
  "url": "https://research.draconitic.com/paper/d4vwy4fvzfx7z",
  "venue": "bioRxiv",
  "versions": []
}