{
  "abstract": "Background:: Tremor may recur after magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy, and the optimal target for deep brain stimulation (DBS) rescue remains uncertain.\n\nCases:: A 71-year-old man with recurrent essential tremor after ventral intermediate nucleus (Vim) MRgFUS underwent DBS along a Vim-posterior subthalamic area (PSA) trajectory. Microelectrode activity was attenuated in the lesioned thalamus; Vim test stimulation was ineffective, whereas PSA stimulation suppressed tremor. A 79-year-old man with recurrent tremor after staged bilateral MRgFUS underwent left DBS targeting the rubral wing.\n\nConclusions:: When the original thalamic target is anatomically or physiologically altered, targeting intact cerebellothalamic pathways provides a rational rescue strategy.\n\nHighlights: Deep brain stimulation can remain effective after failed focused ultrasound thalamotomy. These cases illustrate a lesion-informed, network-based strategy that preserves access to the cerebellothalamic network when prior lesioning has altered local anatomy or physiology.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada",
    "Department of Neurosurgery, Pontifical Catholic University of Chile, Santiago, Chile"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Francisco Aranda Godoy"
    },
    {
      "affs": [
        0
      ],
      "name": "Evan Wilson"
    },
    {
      "affs": [
        0
      ],
      "name": "Danielle Pietramalla"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher R. Honey",
      "orcid": "0000-0003-2601-6652"
    },
    {
      "affs": [
        0
      ],
      "name": "Stefan Lang",
      "orcid": "0000-0001-8960-0640"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d5158rnd73f42.bib",
  "cited_by": 0,
  "doi": "10.5334/tohm.1279",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741935/",
  "id": "d5158rnd73f42",
  "issns": [
    "2160-8288"
  ],
  "landing_url": "https://doi.org/10.5334/tohm.1279",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Reports"
    ],
    [
      "openalex",
      "2728|Deep Brain Stimulation and Movement Disorders"
    ]
  ],
  "openalex": "W7225185225",
  "pdf_url": "https://tremorjournal.org/articles/1279/files/6ae9e05c8a09a.pdf",
  "pmcid": "PMC13741935",
  "pmid": "42997502",
  "published": "2026-11-03",
  "publisher": "Ubiquity Press",
  "ris": "https://research.draconitic.com/paper/d5158rnd73f42.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:52Z",
      "native_id": "PMC13741935",
      "source": "pmc",
      "url": "https://doi.org/10.5334/tohm.1279"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Deep Brain Stimulation and Movement Disorders",
      "subfield": "neurology"
    }
  ],
  "title": "Network-Based Deep Brain Stimulation Rescue After Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Two Targeting Strategies",
  "title_text": "Network-Based Deep Brain Stimulation Rescue After Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Two Targeting Strategies",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:52Z",
  "url": "https://research.draconitic.com/paper/d5158rnd73f42",
  "venue": "Tremor and Other Hyperkinetic Movements",
  "versions": []
}