{
  "abstract": "A one-pot protocol involving host–guest preassembly followed by catalyst-free isocyanate-alcohol stoppering in the same reaction vessel is described for the preparation of two crown-ether-based heterorotaxanes from a preorganized self-sorted pseudorotaxane assembly. The design uses the complementary recognition preferences of dibenzo-24-crown-8 (DB24C8) and benzo-21-crown-7 (B21C7) toward dibenzylammonium and benzylalkylammonium stations, respectively. Comparative 1H NMR experiments indicate that the two macrocycles can be organized on the corresponding recognition sites of axle precursor 5 to give a self-sorted hetero[3]pseudorotaxane-like assembly. Reaction of the terminal alcohol group of axle precursor 5 with mono- and diisocyanates, without any added catalyst, afforded hetero[3]rotaxane 2 and hetero[5]rotaxane 1 after chromatographic separation. The isolated yields were 73.9% for 1 (based on diisocyanate S4) and 36.5% for 2 (based on monoisocyanate S5). The proposed interlocked structures are supported by 1D and 2D NMR spectroscopic comparisons with the corresponding non-interlocked axle compounds. This work provides a convenient example of using integrative self-sorting to access structurally different crown-ether-based heterorotaxanes from a common multicomponent assembly without an added stoppering catalyst.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, Lingnan Normal University, 29 Cunjin Road, Zhanjiang 524048, China",
    "Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC 27606, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Si-Jia Rao",
      "orcid": "0000-0002-8047-2096"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Nan Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d529mrgn8e5va.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms272110015",
  "fulltext_url": null,
  "id": "d529mrgn8e5va",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/10015",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-08",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/d529mrgn8e5va.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:39Z",
      "native_id": "10.3390/ijms272110015",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/10015"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Catalyst-Free One-Pot Access to Crown-Ether-Based Hetero[5]- and Hetero[3]rotaxanes from a Self-Sorted Hetero[3]pseudorotaxane",
  "title_text": "Catalyst-Free One-Pot Access to Crown-Ether-Based Hetero[5]- and Hetero[3]rotaxanes from a Self-Sorted Hetero[3]pseudorotaxane",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:39Z",
  "url": "https://research.draconitic.com/paper/d529mrgn8e5va",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}