{
  "abstract": "Formation of autoantibodies to transglutaminase 2 (TG2) in celiac disease likely involves TG2-gluten complexes that allow gluten-specific CD4+ T cells to provide help to TG2-specific B cells. To investigate whether TG2 derived from intestinal epithelial cells (IECs) contributes to this process, we generated mice with inducible IEC-specific expression of TG2 fused to a deamidated gluten peptide (DGP) containing a T-cell epitope. Upon induction, the TG2-DGP fusion protein was expressed in IECs and released into the intestinal lumen. In HLA-DQ2.5 transgenic mice with activated gluten-specific CD4+ T cells and naive TG2-specific B cells, expression of TG2-DGP was immunogenic and drove the production of intestinal and systemic anti-TG2 autoantibodies. TG2-specific B cells predominantly expanded in Peyers patches, suggesting that their priming and subsequent differentiation into lamina propria TG2-specific IgA+ plasma cells occurs in gut-associated lymphoid tissues. The findings demonstrate immunogenicity of IEC-derived TG2-DGP fusion antigen supporting the notion of a pathogenic role for luminal TG2 in driving anti-TG2 autoimmunity in celiac disease.",
  "abstract_shown": true,
  "affiliations": [
    "Oslo University Hospital"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "R. I. Loberg"
    },
    {
      "name": "H. A. Abdi-Dezfuli"
    },
    {
      "name": "L. Kleppa"
    },
    {
      "name": "A. E. Dewan"
    },
    {
      "name": "M. T. Meling"
    },
    {
      "name": "L. M. Sollid"
    },
    {
      "affs": [
        0
      ],
      "name": "M. F. du Pre"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d56m4s4my8gvc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.01.748464",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748464v1.full",
  "id": "d56m4s4my8gvc",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748464v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "openalex",
      "2715|Celiac Disease Research and Management"
    ]
  ],
  "openalex": "W7210261822",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748464v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d56m4s4my8gvc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:47Z",
      "native_id": "10.64898/2026.09.01.748464",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748464v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies",
  "title_text": "Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:47Z",
  "url": "https://research.draconitic.com/paper/d56m4s4my8gvc",
  "venue": "bioRxiv",
  "versions": []
}