{
  "abstract": "Background\n\nAs populations age, cardiovascular disease (CVD) increasingly affects functional independence, an issue of growing importance among older adults. However, long-term trajectories of functional decline in patients receiving contemporary CVD care remain poorly characterized, so the Niigata Cardiovascular Disease Registry using Health Insurance Claims (NiCARDIA) was established to address this gap by integrating hospital-based clinical data with administrative datasets through a prefecture-wide data-sharing platform.Methods and results\n\nNiCARDIA is a multicenter, prospective observational cohort enrolling 8,500 adults hospitalized with CVD at 16 hospitals across Niigata Prefecture, Japan. Baseline data include demographics, biomarkers, echocardiographic findings, and other clinical variables. Eligible participants are insured under Japan's public health insurance schemes, enabling deterministic linkage to longitudinal medical, long-term care, and health check-up data. Administrative datasets will be updated every 6-12 months through to 2045. The primary outcome is longitudinal change in functional independence assessed by certified long-term care-need levels. Secondary outcomes include death, hospitalizations, treatment patterns, and prediction of functional decline.Conclusions\n\nBy linking detailed clinical data with population-level administrative datasets, NiCARDIA will enable comprehensive evaluation of long-term functional trajectories and their clinical and social determinants in contemporary CVD patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular and Medicine, Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.",
    "Department of Cardiovascular and Medicine, Tachikawa General Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Niigata Prefectural Shibata Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Niigata City General Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Niigata Medical Center Niigata Japan.",
    "Department of Cardiovascular and Medicine, Niigata Prefectural Central Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Saiseikai Niigata Kenoh Kikan Hospital Niigata Japan.",
    "Department of Cardiology, Nagaoka Chuo General Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Nagaoka Red Cross Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Kido Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Sado General Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Shinrakuen Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, JA Niigata Kouseiren Kashiwazaki General Hospital and Medical Center Niigata Japan.",
    "Department of Cardiovascular and Medicine, Saiseikai Niigata Hospital Niigata Japan.",
    "Department of Internal Medicine, Niigata Minami Hospital Niigata Japan.",
    "Department of Cardiovascular and Medicine, Uonuma Kikan Hospital Niigata Japan.",
    "Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.",
    "Clinical and Translational Research Center, Niigata University Medical and Dental Hospital Niigata Japan.",
    "Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences Niigata Japan."
  ],
  "article_type": "methods article",
  "arxiv": null,
  "author_total": 28,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shinya Fujiki"
    },
    {
      "affs": [
        0
      ],
      "name": "Hayao Ikesugi"
    },
    {
      "affs": [
        0
      ],
      "name": "Akari Hagiwara"
    },
    {
      "affs": [
        1
      ],
      "name": "Minoru Takahashi"
    },
    {
      "affs": [
        2
      ],
      "name": "Tsuyoshi Yoshida"
    },
    {
      "affs": [
        3
      ],
      "name": "Kazuyoshi Takahashi"
    },
    {
      "affs": [
        4
      ],
      "name": "Asako Tomii"
    },
    {
      "affs": [
        5
      ],
      "name": "Takashi Saikawa"
    },
    {
      "affs": [
        6
      ],
      "name": "Yasushi Miyakita"
    },
    {
      "affs": [
        7
      ],
      "name": "Yuichi Nakamura"
    },
    {
      "affs": [
        8
      ],
      "name": "Makoto Tomita"
    },
    {
      "affs": [
        9
      ],
      "name": "Toshio Yamaguchi"
    },
    {
      "affs": [
        10
      ],
      "name": "Keisuke Suzuki"
    },
    {
      "affs": [
        11
      ],
      "name": "Shunsuke Imai"
    },
    {
      "affs": [
        12
      ],
      "name": "Toru Ida"
    },
    {
      "affs": [
        13
      ],
      "name": "Katsuharu Hatada"
    },
    {
      "affs": [
        14
      ],
      "name": "Satoru Abe"
    },
    {
      "affs": [
        15
      ],
      "name": "Masataka Arita"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryohei Sakai"
    },
    {
      "affs": [
        0
      ],
      "name": "Hiromi Kayamori"
    },
    {
      "affs": [
        0
      ],
      "name": "Tsugumi Takayama"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeshi Kashimura"
    },
    {
      "affs": [
        16
      ],
      "name": "Yiwei Ling"
    },
    {
      "affs": [
        16
      ],
      "name": "Shujiro Okuda"
    },
    {
      "affs": [
        17
      ],
      "name": "Haruna Miyazawa"
    },
    {
      "affs": [
        17
      ],
      "name": "Takahiro Tanaka"
    },
    {
      "affs": [
        18
      ],
      "name": "Hirohito Sone"
    },
    {
      "affs": [
        0
      ],
      "name": "Takayuki Inomata"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d56r7a1ej0zqr.bib",
  "cited_by": 0,
  "doi": "10.1253/circrep.cr-26-0029",
  "fulltext_url": "https://europepmc.org/articles/PMC13747996",
  "id": "d56r7a1ej0zqr",
  "issns": [
    "2434-0790"
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  "landing_url": "https://europepmc.org/article/MED/43011238",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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  "native_subjects": [
    [
      "heading",
      "Protocol Paper"
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      "2713|Chronic Disease Management Strategies"
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  "pdf_url": "https://europepmc.org/articles/PMC13747996?pdf=render",
  "pmcid": "PMC13747996",
  "pmid": "43011238",
  "published": "2026-09-04",
  "publisher": "The Japanese Circulation Society",
  "ris": "https://research.draconitic.com/paper/d56r7a1ej0zqr.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:25:13Z",
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    {
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      "native_id": "PMC13747996",
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      "url": "https://doi.org/10.1253/circrep.cr-26-0029"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Chronic Disease Management Strategies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Design and Rationale of the Niigata Cardiovascular Disease Registry Using Linked Administrative and Clinical Data (NiCARDIA).",
  "title_text": "Design and Rationale of the Niigata Cardiovascular Disease Registry Using Linked Administrative and Clinical Data (NiCARDIA).",
  "type": "peer-reviewed",
  "updated_at": "2026-11-14T03:20:07Z",
  "url": "https://research.draconitic.com/paper/d56r7a1ej0zqr",
  "venue": "Circulation reports",
  "versions": []
}