{
  "abstract": "The important substitution of costly palladium catalysts with earth-abundant nickel alternatives in Suzuki-Miyaura cross-coupling reactions is still problematic for challenging substrates, such as heteroaryls and (hetero)aryl chlorides. In this context, we report the application of low Vbur and electron-rich biaryl-based phosphasilinane ligands in nickel-catalyzed Suzuki-Miyaura cross-coupling reaction of electron-rich (hetero)aryl-chlorides with aryl boronic acid substrates, at catalyst loadings as low as 0.5 mol-% on gram-scale synthesis. To overcome the use of unstable Ni(0)-sources, the activation of cheap and bench-stable L2NiCl2 precatalysts with boronic acids was investigated and successfully applied, e.g., in the synthesis of intermediates for agrochemical and pharmaceutical products. Furthermore, this method enabled the synthesis of bench- and base-stable L2Ni(3-furyl)Cl complex, which was directly applied in cross-coupling reactions.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Christoph Kremser"
    },
    {
      "name": "Dino Berthold"
    },
    {
      "name": "Alexander F. Siegle"
    },
    {
      "name": "Oliver Trapp",
      "orcid": "0000-0002-3594-5181"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d5r3351w03yyv.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009720/v1",
  "fulltext_url": null,
  "id": "d5r3351w03yyv",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009720/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic Cross-Coupling Reactions"
    ]
  ],
  "openalex": "W7215034097",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009720/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/d5r3351w03yyv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009720",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009720/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Cross-Coupling Reactions",
      "subfield": "organic"
    }
  ],
  "title": "In situ Activation of Ni(II) with Boronic Acids and Application of a Phosphasilinane Ligand enable the Suzuki-Miyaura Cross-Coupling of Deactivated (Hetero)Aryl Chlorides",
  "title_text": "In situ Activation of Ni(II) with Boronic Acids and Application of a Phosphasilinane Ligand enable the Suzuki-Miyaura Cross-Coupling of Deactivated (Hetero)Aryl Chlorides",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/d5r3351w03yyv",
  "venue": "ChemRxiv",
  "versions": []
}