{
  "abstract": "Renal fibrosis represents the final common pathway of chronic kidney disease (CKD) progression and remains a major therapeutic challenge. Fibroblast growth factor receptor 3 (FGFR3) has emerged as a context-dependent component of fibroblast growth factor (FGF) signaling, but its renal role remains incompletely defined because direct receptor-specific evidence is scarce. This review integrates kidney-specific FGFR3 studies with endocrine FGF23–Klotho biology and broader FGF/FGFR networks using an explicit evidence hierarchy. Current direct renal evidence is limited to two 2025 experimental studies: an FGF18-associated FGFR3–AMPK–NOX4 program that attenuated folic acid-induced fibrosis, and a single toxicant model reporting an FGF9–FGFR3–PI3K/Akt program associated with fibroblast proliferation. The latter requires independent replication before generalization beyond toxicant nephropathy. By contrast, physiological renal FGF23 signaling is best established through FGFR1c–α-Klotho, whereas the strongest evidence for Klotho-independent pathological FGF23 signaling involves FGFR4 in cardiovascular tissues; direct evidence that FGF23 promotes renal fibrosis specifically through FGFR3 is lacking. Accordingly, FGFR3 should be viewed as an emerging, ligand- and compartment-dependent signaling component rather than a validated CKD therapeutic target. Future priorities include human kidney spatial and phosphoproteomic profiling, cell-specific FGFR3 perturbation, longitudinal FGF23/Klotho biomarker studies, and mechanism-based evaluation of FGFR-directed strategies with integrated renal and mineral-metabolism endpoints.",
  "abstract_shown": true,
  "affiliations": [
    "Jilin Medical University, Jilin 132013, China",
    "National Engineering Research Center of Cell Growth Factor Drugs and Protein Preparations (Jilin Center), Jilin 132013, China",
    "Jilin Jinuo Biological Engineering Co., Ltd., Changchun 130600, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ying Fu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hengping Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Lei Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huiyan Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d5wc6btrj2zmm.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101431",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702723/?tool=EBI",
  "id": "d5wc6btrj2zmm",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1431",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Fibroblast Growth Factor Research"
    ]
  ],
  "openalex": "W7216242901",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702723/pdf/?tool=EBI",
  "pmcid": "PMC13702723",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/d5wc6btrj2zmm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101431",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1431"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13702723",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702723"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Fibroblast Growth Factor Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Emerging Roles of FGFR3 and FGF23-Associated Signaling in Renal Fibrosis: Molecular Integration, Clinical Correlates, and Therapeutic Perspectives",
  "title_text": "Emerging Roles of FGFR3 and FGF23-Associated Signaling in Renal Fibrosis: Molecular Integration, Clinical Correlates, and Therapeutic Perspectives",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/d5wc6btrj2zmm",
  "venue": "Biomolecules",
  "versions": []
}