{
  "abstract": "Efficient and sustainable cleavage of α-O-4 ether linkages is a critical initial step in lignin valorization. In this study, we present two highly effective catalytic protocols for the cleavage of C–O bonds in lignin α-O-4 model compounds under mild conditions (100 °C) that do not require organic solvents. Benzyl phenyl ether and its derivatives undergo quantitative conversion at 100 °C in the absence of an organic solvent under two contrasting conditions: aqueous trifluoromethanesulfonic acid (TfOH) yields the hydrolysis products phenol and benzyl alcohol, whereas solid superacid Nafion NR50 yields benzyl-migrated recombination products predominantly under solvent-free conditions. Nafion NR50 was recovered and reused for five consecutive cycles with conversion maintained within experimental error of activity. Non-fluorinated resins undergo the same transformation more slowly, which suggests that a perfluorinated acid is unnecessary. The medium-control principle established here defines the conditions under which condensation can be suppressed during acid-mediated α-O-4 cleavage.",
  "abstract_shown": true,
  "affiliations": [
    "Gifu University , , 1-1, Yanagido , ,",
    "Gifu University , , 1-1 Yanagido , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shota Mizuno",
      "orcid": "0000-0002-7071-3642"
    },
    {
      "affs": [
        0
      ],
      "name": "Koshiro Yamaguchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yasuhiro Kubota",
      "orcid": "0000-0002-9177-4364"
    },
    {
      "affs": [
        1
      ],
      "name": "Toshiyasu Inuzuka"
    },
    {
      "affs": [
        0
      ],
      "name": "Kazumasa Funabiki",
      "orcid": "0000-0002-7880-6093"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d60kthmtk93z3.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05568",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670879/?tool=EBI",
  "id": "d60kthmtk93z3",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13670879",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Lignin and Wood Chemistry"
    ]
  ],
  "openalex": "W7215055308",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670879/pdf/?tool=EBI",
  "pmcid": "PMC13670879",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/d60kthmtk93z3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13670879",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13670879"
    },
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c05568",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/40/61291/5443624/Hydrolysis-of-Lignin-O-4-Model-Compounds-Using"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2470-1343",
      "subfield": "general"
    }
  ],
  "title": "Hydrolysis of Lignin α‑O‑4 Model Compounds Using Strong Acid Catalyst in Water",
  "title_text": "Hydrolysis of Lignin α‑O‑4 Model Compounds Using Strong Acid Catalyst in Water",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:39Z",
  "url": "https://research.draconitic.com/paper/d60kthmtk93z3",
  "venue": "ACS omega",
  "versions": []
}