{
  "abstract": "The GALFLU trial showed a lower incidence of hospitalization among adults aged 65–79 years randomized to high-dose inactivated influenza vaccine (HD-IIV) vs standard-dose inactivated influenza vaccine (SD-IIV). This Bayesian re-analysis estimated >80% probability of benefit (relative vaccine effectiveness >10%) against influenza- or pneumonia-related hospitalization, supporting the benefit of HD-IIV over SD-IIV.\n\nClinical Trials Registration. GALFLU ClinicalTrials.gov (NCT06141655); EudraCT (2023-506977-36-00).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "name": "Jacobo Pardo-Seco"
    },
    {
      "name": "Carmen Rodriguez-Tenreiro-Sánchez"
    },
    {
      "name": "Iago Giné-Vázquez",
      "orcid": "0000-0002-6725-2638"
    },
    {
      "name": "Narmeen Mallah",
      "orcid": "0000-0002-3711-3792"
    },
    {
      "name": "Susana Mirás-Carballal"
    },
    {
      "name": "Marta Piñeiro-Sotelo"
    },
    {
      "name": "Martín Cribeiro González"
    },
    {
      "name": "Mónica Conde Pájaro"
    },
    {
      "name": "Juan-Manuel González-Pérez"
    },
    {
      "name": "Irene Rivero-Calle",
      "orcid": "0000-0002-3678-9264"
    },
    {
      "name": "Xabier Bello",
      "orcid": "0000-0002-4990-8496"
    },
    {
      "name": "Josefina L Razzini"
    },
    {
      "name": "Antonio Salas",
      "orcid": "0000-0002-2336-702X"
    },
    {
      "name": "Rebecca C Harris"
    },
    {
      "name": "Matthew M Loiacono"
    },
    {
      "name": "Robertus van Aalst",
      "orcid": "0000-0003-3025-7811"
    },
    {
      "name": "Manel Farre",
      "orcid": "0009-0001-6345-1656"
    },
    {
      "name": "Marine Dufournet"
    },
    {
      "name": "Niklas Dyrby Johansen",
      "orcid": "0000-0001-6959-3236"
    },
    {
      "name": "Daniel Modin"
    },
    {
      "name": "Tor Biering-Sørensen"
    },
    {
      "name": "Carmen Duran-Parrondo"
    },
    {
      "name": "Federico Martinón-Torres",
      "orcid": "0000-0002-9023-581X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d6evewdjkrsdt.bib",
  "cited_by": 0,
  "doi": "10.1093/cid/ciag466",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715985/",
  "id": "d6evewdjkrsdt",
  "issns": [
    "1058-4838",
    "1537-6591"
  ],
  "landing_url": "https://doi.org/10.1093/cid/ciag466",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00290"
    ],
    [
      "heading",
      "Brief Report"
    ],
    [
      "heading",
      "Vaccines"
    ],
    [
      "openalex",
      "2713|Influenza Virus Research Studies"
    ]
  ],
  "openalex": "W7172326579",
  "pdf_url": null,
  "pmcid": "PMC13715985",
  "pmid": "42546169",
  "published": "2026-08-03",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/d6evewdjkrsdt.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:09Z",
      "native_id": "PMC13715985",
      "source": "pmc",
      "url": "https://doi.org/10.1093/cid/ciag466"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Influenza Virus Research Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "A Bayesian Re-analysis of the GALFLU Trial of High-Dose vs Standard-Dose Influenza Vaccine Against Hospitalization Outcomes",
  "title_text": "A Bayesian Re-analysis of the GALFLU Trial of High-Dose vs Standard-Dose Influenza Vaccine Against Hospitalization Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:09Z",
  "url": "https://research.draconitic.com/paper/d6evewdjkrsdt",
  "venue": "Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America",
  "versions": []
}