{
  "abstract": "Over the last 30 years, two population-scale health crises have emerged as the epidemic of diet-related cardiometabolic disease (obesity, type 2 diabetes, hypertension, and cardiovascular disease) and the spread of antimicrobial resistance (AMR) as a major cause of death globally. Typically, they are investigated and controlled independently of each other. AMR may be amplified by diet-induced cardiometabolic dysfunction, which is not a parallel but an upstream, under-recognized burden. We describe four convergent pathways that might contribute to the increased risk of resistance. Impaired host immunity leading to recurrent, difficult-to-treat infection and repeated antibiotic exposure; obesity-associated pharmacokinetic changes leading to subtherapeutic antibiotic concentrations in the system; diet-induced gut dysbiosis that increases the reservoir of antibiotic-resistance genes (the gut resistome); and a bidirectional loop in which cumulative antibiotic exposure itself seems to increase cardiovascular risk. We then placed functional foods, nutraceuticals, and specific bioactive compounds as dual-action levers that act on the metabolic driver and, for a subset of molecules, directly on bacterial fitness, virulence, or the resistome. The clearest single-molecule example is developed in the form of berberine, which provides metabolic correction through the AMPK pathway, while simultaneously providing FtsZ-targeting and efflux-modulating antibacterial activity. We propose a testable framework, the metabolic–AMR augmentation loop, and highlight the gaps in evidence for longitudinal and interventional studies. If this framework proves to be robust, then diet-induced metabolic dysfunction correction could become a viable AMR-mitigation strategy on its own and one not currently employed in existing stewardship programs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology, School of Life Sciences, Federal University of Technology Akure, Akure, Nigeria",
    "Department of Biochemistry, School of Life Sciences, Federal University of Technology Akure, Akure, Nigeria",
    "Teddy Bioscience Laboratory, Ilara-Mokin, Nigeria",
    "Department of Microbiology, Adekunle Ajasin University, Akungba-Akoko, Nigeria",
    "Food Science and Agricultural Chemistry, School of Environmental and Agricultural Sciences, McGill University, Montreal, QC, Canada",
    "Department of Food Science and Technology, School of Agriculture and Agricultural Technology, Federal University of Technology Akure, Akure, Nigeria"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Michael Tosin Bayode"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Bashirat Akinbami"
    },
    {
      "affs": [
        1
      ],
      "name": "Christianah Titilayo Oladele"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Ayomide Faith Okiti"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Esther Oluwadarasimi Oyedeji"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d6kzdc826y824.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1977386",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13697305/",
  "id": "d6kzdc826y824",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://doi.org/10.3389/fpubh.2026.1977386",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7221550517",
  "pdf_url": "https://europepmc.org/articles/PMC13697305?pdf=render",
  "pmcid": "PMC13697305",
  "pmid": "42936337",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/d6kzdc826y824.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:23Z",
      "native_id": "PMC13697305",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpubh.2026.1977386"
    },
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1977386",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1977386/full"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42936337",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42936337"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Diet-driven cardiometabolic dysfunction as a potential amplifier of antimicrobial resistance: mechanistic evidence, gut resistome ecology, and dual-action nutraceutical interventions",
  "title_text": "Diet-driven cardiometabolic dysfunction as a potential amplifier of antimicrobial resistance: mechanistic evidence, gut resistome ecology, and dual-action nutraceutical interventions",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:22Z",
  "url": "https://research.draconitic.com/paper/d6kzdc826y824",
  "venue": "Frontiers in Public Health",
  "versions": []
}