{
  "abstract": "A total synthesis of the macrocyclic depsipeptides nat-(−)-cochinmicin I and nat-(+)–cochinmicin V is reported. A key feature of all known cochinmicins is a macrocycle feature formed by the C-terminal 3,5-dihydroxy phenyl glycinamide (Dpg7) to a conserved d-allo-threonine residue (i → i + 4). Both epimers of the macrocyclic ester are natural products (cochinmicins I and V). Here we report an approach using Umpolung Amide Synthesis (UmAS) to avoid risk of epimerization at the d-Dpg6 residue. The Mioskowski–Nef reaction is used to divert a nitroalkane common to both Dpg residues toward ester formation between Dpg7 and the d-allo-threonine residue.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University Nashville Tennessee 37235 USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jade C. Williams"
    },
    {
      "affs": [
        0
      ],
      "name": "Preston C. Gourville"
    },
    {
      "affs": [
        0
      ],
      "name": "Chase K. Pyrah"
    },
    {
      "affs": [
        0
      ],
      "name": "William J. Stark"
    },
    {
      "affs": [
        0
      ],
      "name": "Jade A. Bing",
      "orcid": "0000-0002-6282-4932"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeffrey N. Johnston",
      "orcid": "0000-0002-0885-636X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d6pt9nbcve5ss.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc05662h",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735797/",
  "id": "d6pt9nbcve5ss",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc05662h",
  "language": "en",
  "licence": "CC-BY-NC-3.0",
  "licence_label": "CC BY-NC 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Chemical Synthesis and Analysis"
    ]
  ],
  "openalex": "W7225337821",
  "pdf_url": "https://pubs.rsc.org/sc/article-pdf/doi/10.1039/d6sc05662h/15046206/d6sc05662h.pdf",
  "pmcid": "PMC13735797",
  "pmid": "42991349",
  "published": "2026-11-05",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/d6pt9nbcve5ss.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:25Z",
      "native_id": "PMC13735797",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc05662h"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Chemical Synthesis and Analysis",
      "subfield": "organic"
    }
  ],
  "title": "Total synthesis of cochinmicin I and V",
  "title_text": "Total synthesis of cochinmicin I and V",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:25Z",
  "url": "https://research.draconitic.com/paper/d6pt9nbcve5ss",
  "venue": "Chemical Science",
  "versions": []
}