{
  "abstract": "Background\n\nDyslipidaemia may contribute to age-related cataract through altered lens membrane homeostasis, oxidative stress and lipid peroxidation, but clinical evidence remains inconsistent.Objective\n\nTo compare serum lipid profiles in adults with and without age-related cataract and quantify the independent associations of specific lipid abnormalities with cataract.Methods\n\nThis hospital-based case-control study included 300 adults aged 50 years or older at a tertiary care centre in Kanpur, India, from April 2024 to October 2025. Cases were 150 patients with age-related cataract, and controls were 150 participants without cataract. Patients with diabetes, secondary cataract or lipid-lowering therapy were excluded. Fasting total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic colourimetry. Separate multivariable logistic regression models adjusted each lipid abnormality for age, sex, education, occupation, smoking, alcohol use and socioeconomic status.Results\n\nCases were older than controls (63.07 ± 6.14 vs 60.70 ± 6.67 years; p = 0.002). Compared with controls, cases had higher total cholesterol (209.62 ± 33.23 vs 183.10 ± 28.08 mg/dL), triglycerides (169.42 ± 34.47 vs 146.65 ± 27.12 mg/dL), LDL-C (138.69 ± 30.45 vs 119.17 ± 21.27 mg/dL) and VLDL-C (33.89 ± 6.89 vs 29.33 ± 5.42 mg/dL), and lower HDL-C (39.49 ± 5.90 vs 45.95 ± 6.75 mg/dL; all p < 0.001). Adjusted odds of cataract were higher with low HDL-C (adjusted odds ratio {aOR} 3.91, 95% confidence interval {CI} 2.22-6.89), high LDL-C (aOR 3.06, 95% CI 1.86-5.04), high VLDL-C (aOR 3.03, 95% CI 1.84-5.00), high triglycerides (aOR 2.69, 95% CI 1.64-4.43) and high total cholesterol (aOR 2.49, 95% CI 1.54-4.05). Lipid distributions did not differ significantly across the 15 recorded cataract morphology categories.Conclusion\n\nDyslipidaemia, particularly low HDL-C and elevated atherogenic lipids, was independently associated with age-related cataract in this hospital population. These findings identify a clinically relevant metabolic correlate but do not establish causality. Prospective population-based studies should determine whether lipid abnormalities predict cataract onset or progression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, IND.",
    "Department of Biochemistry, Rama Medical College Hospital and Research Centre, Kanpur, IND."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruchika Agarwal"
    },
    {
      "affs": [
        0
      ],
      "name": "Sakshi Bhandari"
    },
    {
      "affs": [
        0
      ],
      "name": "Pallavi Dhawan"
    },
    {
      "affs": [
        1
      ],
      "name": "Pawan A Kulkarni"
    },
    {
      "affs": [
        0
      ],
      "name": "Namrata Prasad"
    },
    {
      "affs": [
        0
      ],
      "name": "Sadaf Khan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d6t75wb05t0j5.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.117339",
  "fulltext_url": "https://europepmc.org/articles/PMC13723720",
  "id": "d6t75wb05t0j5",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42968867",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Ophthalmology"
    ],
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7216259481",
  "pdf_url": "https://europepmc.org/articles/PMC13723720?pdf=render",
  "pmcid": "PMC13723720",
  "pmid": "42968867",
  "published": "2026-10-01",
  "publisher": "Cureus Inc.",
  "ris": "https://research.draconitic.com/paper/d6t75wb05t0j5.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42968867",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42968867"
    },
    {
      "first_seen": "2026-11-04T12:22:18Z",
      "native_id": "PMC13723720",
      "source": "pmc",
      "url": "https://doi.org/10.7759/cureus.117339"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Serum Lipid Abnormalities and Age-Related Cataract: A Hospital-Based Case-Control Study in North India.",
  "title_text": "Serum Lipid Abnormalities and Age-Related Cataract: A Hospital-Based Case-Control Study in North India.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:29Z",
  "url": "https://research.draconitic.com/paper/d6t75wb05t0j5",
  "venue": "Cureus",
  "versions": []
}