{
  "abstract": "Objective\n\nTo investigate whether Progesterone Receptor (PGR) variants +331G/A (rs10895068) and V660L (rs1042838, a PROGINS proxy) are associated with Endometrial Polyps (EP) in postmenopausal women undergoing hysteroscopy.Methods\n\nThis exploratory case-control study included 236 histopathologically confirmed EP cases and 73 hysteroscopy-negative controls from the same institution and period, unmatched. All eligible hysteroscopy-negative women during the study period were included, with no declinations. Genotyping of +331G/A and V660L was performed by PCR-HRM. Genetic comparisons used two-sided tests and multivariable logistic regression, with minimum detectable odds ratios estimated for 80% power at α = 0.05. Hormone Therapy (HT) and tamoxifen use were recorded as binary variables reflecting current use at hysteroscopy.Results\n\nGenotype distributions did not differ between groups for +331G/A (p = 0.245) or V660L (p = 0.435); call rates were 100% for both variants. Neither +331G/A nor V660L carrier status was significantly associated with EP after adjustment (aOR = 0.43, 95% CI 0.17-1.09, p = 0.074; and aOR = 0.59, 95% CI 0.31-1.11, p = 0.100, respectively). Current HT use was inversely associated with EP (aOR = 0.15, 95% CI 0.06-0.40; p < 0.001), though regimen data were unavailable. Genetic associations remained non-significant in the model excluding HT.Conclusion\n\nNeither PGR variant was significantly associated with EP. The sample could detect only relatively large effects, so smaller genetic associations cannot be excluded. The inverse association with binary HT exposure is hypothesis-generating rather than causal, given incomplete exposure characterization and the possibility of selection or residual confounding.",
  "abstract_shown": true,
  "affiliations": [
    "Video Endoscopy and Endometriosis Section of The Gynecology Department, Centro Universitário Faculdade de Medicina do ABC, Santo André, SP, Brazil. Electronic address: milton@wajman.com.br.",
    "Video Endoscopy and Endometriosis Section of The Gynecology Department, Centro Universitário Faculdade de Medicina do ABC, Santo André, SP, Brazil.",
    "Department of Obstetrics and Gynecology, Centro Universitário Faculdade de Medicina do ABC, Santo André, SP, Brazil.",
    "Gynecology Department, Centro Universitário Faculdade de Medicina do ABC, Santo André, SP, Brazil.",
    "Urogynecology Section of The Gynecology Department, Centro Universitário Faculdade de Medicina do ABC, Santo André, SP, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Milton Wajman"
    },
    {
      "affs": [
        1
      ],
      "name": "Marcos Tcherniakovsky",
      "orcid": "0000-0002-5342-6377"
    },
    {
      "affs": [
        1
      ],
      "name": "Marina Martinelli Sonnenfeld"
    },
    {
      "affs": [
        1
      ],
      "name": "Marta Maria Arcoverde Cavalcanti Meniconi"
    },
    {
      "affs": [
        2
      ],
      "name": "Marília Franco de Oliveira"
    },
    {
      "affs": [
        1
      ],
      "name": "Thomas Moscovitz",
      "orcid": "0000-0001-5993-7285"
    },
    {
      "affs": [
        1
      ],
      "name": "Rogers Camargo Mariano da Silva"
    },
    {
      "affs": [
        3
      ],
      "name": "César Eduardo Fernandes"
    },
    {
      "affs": [
        4
      ],
      "name": "Emerson de Oliveira"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d7av3p3z5zwjv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.clinsp.2026.101216",
  "fulltext_url": "https://europepmc.org/articles/PMC13691488",
  "id": "d7av3p3z5zwjv",
  "issns": [
    "1807-5932",
    "1980-5322"
  ],
  "landing_url": "https://europepmc.org/article/MED/42880132",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7222253746",
  "pdf_url": "https://europepmc.org/articles/PMC13691488?pdf=render",
  "pmcid": "PMC13691488",
  "pmid": "42880132",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d7av3p3z5zwjv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42880132",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42880132"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Progesterone receptor variants and hormone therapy use in postmenopausal endometrial polyps: a case-control study.",
  "title_text": "Progesterone receptor variants and hormone therapy use in postmenopausal endometrial polyps: a case-control study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/d7av3p3z5zwjv",
  "venue": "Clinics (Sao Paulo, Brazil)",
  "versions": []
}