{
  "abstract": "The progressive expansion of indications for Transcatheter Aortic Valve Implantation (TAVI) towards lower-risk and younger populations has raised concerns about potential outcome attenuation with increasing procedural volumes. Real-world evidence addressing this concern is limited. To assess temporal trends in patient characteristics and procedural outcomes of TAVI in a large nationwide cohort. The Swiss TAVI Registry prospectively enrolled consecutive patients undergoing TAVI in Switzerland. Baseline characteristics, procedural complications and outcomes were compared across three periods: 2011-2015, 2016-2020 and 2021-2024. The primary endpoint was major adverse cardiovascular events (MACE: all-cause mortality, non-fatal myocardial infarction, and non-fatal stroke) at one year. The secondary endpoint was 30-day MACE. Among 19’452 patients, TAVI volume increased 27% annually. Patient age (82 years) and comorbidity burden remained stable, while the proportion of women increased (51% to 58%) and the median STS score decreased (4.5% to 3.3%). Considering the expansion to lower-risk patients, 1-year MACE declined significantly from 16% to 14% to 9.1% across periods (adjusted HR 0.69, 95% CI 0.62-0.78, p<0.001). Similarly, 30-day MACE decreased from 6.9% to 5.2% to 4.0% (adjusted HR 0.66, 95%CI 0.55-0.78, p<0.001). Procedural mortality declined from 2.9% to 1.2%, periprocedural myocardial infarction from 0.4% to 0.2% and stroke from 3.2% to 2.0% (all p<0.001).Risk-adjusted TAVI outcomes improved continuously despite a significant volume increase, with improvements exceeding those expected from lower-risk patients risk profiles alone.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s12928-026-01310-1.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031, Basel, Switzerland",
    "Department of Cardiology, Triemli Hospital Zurich, Zurich, Switzerland",
    "Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland",
    "Department of Cardiology, Lausanne University Hospital – CHUV, Lausanne, Switzerland",
    "Department of Cardiac Surgery, University Hospital Basel, University of Basel, Basel, Switzerland",
    "Department of Cardiology, Heart Center, Cantonal Hospital Lucerne, Lucerne, Switzerland",
    "Department of Cardiovascular Surgery, Cardiocentro Ticino Institute, Lugano, Switzerland",
    "Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland",
    "Cardiovascular Center Zurich, Hirslanden Klinik im Park, Zurich, Switzerland",
    "Division of Cardiology and Cardiovascular Surgery, University Hospital, Geneva, Switzerland",
    "Department of Clinical Research, University of Bern, Bern, Switzerland",
    "Division of Cardiology, University Hospital, Lausanne, Switzerland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Thorald Stolte"
    },
    {
      "affs": [
        0
      ],
      "name": "Jakob Johannes Reichl"
    },
    {
      "affs": [
        1
      ],
      "name": "David Tueller"
    },
    {
      "affs": [
        0
      ],
      "name": "Felix Goetzinger"
    },
    {
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        0
      ],
      "name": "Max Wagener"
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    {
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        2,
        3
      ],
      "name": "Stefan Stortecky"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Raban Jeger"
    },
    {
      "affs": [
        4
      ],
      "name": "Oliver Reuthebuch"
    },
    {
      "affs": [
        5
      ],
      "name": "Stefan Toggweiler"
    },
    {
      "affs": [
        6
      ],
      "name": "Enrico Ferrari"
    },
    {
      "affs": [
        7
      ],
      "name": "Peter Wenaweser"
    },
    {
      "affs": [
        8
      ],
      "name": "Fabian Nietlispach"
    },
    {
      "affs": [
        9
      ],
      "name": "Christoph Huber"
    },
    {
      "affs": [
        9
      ],
      "name": "Marco Roffi"
    },
    {
      "affs": [
        10
      ],
      "name": "Dik Heg"
    },
    {
      "affs": [
        11
      ],
      "name": "David Meier"
    },
    {
      "affs": [
        2
      ],
      "name": "Stephan Windecker"
    },
    {
      "affs": [
        0
      ],
      "name": "Felix Mahfoud"
    },
    {
      "affs": [
        9
      ],
      "name": "Stephane Noble"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Nestelberger",
      "orcid": "0000-0003-2173-5738"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d7f8r6ajft10b.bib",
  "cited_by": 1,
  "doi": "10.1007/s12928-026-01310-1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13719877/",
  "id": "d7f8r6ajft10b",
  "issns": [
    "1868-4300",
    "1868-4297"
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  "landing_url": "https://doi.org/10.1007/s12928-026-01310-1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
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      "2705|Cardiac Valve Diseases and Treatments"
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  "openalex": "W7164855059",
  "pdf_url": null,
  "pmcid": "PMC13719877",
  "pmid": "42298270",
  "published": "2026-06-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d7f8r6ajft10b.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:46Z",
      "native_id": "PMC13719877",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s12928-026-01310-1"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
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  ],
  "title": "Longitudinal Trends and Outcomes in Transcatheter Aortic Valve Implantation: a report from the SwissTAVI Registry",
  "title_text": "Longitudinal Trends and Outcomes in Transcatheter Aortic Valve Implantation: a report from the SwissTAVI Registry",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:51Z",
  "url": "https://research.draconitic.com/paper/d7f8r6ajft10b",
  "venue": "Cardiovascular Intervention and Therapeutics",
  "versions": []
}