{
  "abstract": "Glioblastoma (GB) is an aggressive brain tumor characterized by marked radioresistance and poor clinical outcomes. MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in tumor progression and therapeutic response. Here, we investigated radiation-induced miRNA modulation in patient-derived cancer stem-like cell (CSLC) neurospheres exposed to internal radionuclide therapy using rhenium-188-loaded lipid nanocapsules ( 188 Re-LNC). MiRNA profiling following 188 Re-LNC treatment identified miR-22-3p, miR-197-3p, and miR-574-3p as potential candidates for functional characterization. Lentiviral-mediated overexpression in U87MG cells revealed distinct phenotypes, with miR-22-3p promoting proliferation and clonogenic survival, whereas miR-197-3p primarily enhanced migratory capacity while miR-574-3p had little effect on either phenotype. In an orthotopic murine xenograft model, miR-22-3p and miR-197-3p overexpression accelerated tumor progression and was associated with reduced survival. Notably, upon 188 Re-LNC treatment, miR-22-3p-expressing tumors exhibited pronounced radioresistance, with a complete absence of long-term survivors, while miR-197-3p-expressing tumors remained responsive to therapy. AntagomiR-mediated inhibition of miR-22-3p restored radiosensitivity in vitro and was accompanied by upregulation of the DNA demethylase TET1 that is identified here as a candidate functional target of miR-22-3p. Together, these findings identify miR-22-3p as a critical mediator of GB radioresistance and miR-197-3p as a driver of invasion, supporting their relevance as therapeutic targets and predictive biomarkers to improve radiotherapy stratification and efficacy in GB.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Claire Loussouarn"
    },
    {
      "name": "Loris Roncali"
    },
    {
      "name": "Amandine Etcheverry"
    },
    {
      "name": "Charlotte Roy"
    },
    {
      "name": "Anne Clavreul"
    },
    {
      "name": "Franck Lacœuille"
    },
    {
      "name": "Audrey Rousseau"
    },
    {
      "name": "Jean-Michel Lemée"
    },
    {
      "name": "Philippe Menei"
    },
    {
      "name": "Lucie Karayan-Tapon"
    },
    {
      "name": "Jean Mosser"
    },
    {
      "name": "François Hindré"
    },
    {
      "name": "Patrick Baril"
    },
    {
      "name": "Emmanuel Garcion"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d7mq9jckxgfk4.bib",
  "cited_by": 0,
  "doi": "10.1186/s13046-026-03841-0",
  "fulltext_url": null,
  "id": "d7mq9jckxgfk4",
  "issns": [
    "0392-9078"
  ],
  "landing_url": "https://hal.science/hal-05837199v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.can"
    ],
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7223071443",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "BioMed Central",
  "ris": "https://research.draconitic.com/paper/d7mq9jckxgfk4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05837199",
      "source": "hal",
      "url": "https://hal.science/hal-05837199v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.can",
      "subfield": "oncology"
    }
  ],
  "title": "MiR-22-3p shapes glioblastoma radiation resistance and downregulates the DNA demethylase tumor suppressor TET1",
  "title_text": "MiR-22-3p shapes glioblastoma radiation resistance and downregulates the DNA demethylase tumor suppressor TET1",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/d7mq9jckxgfk4",
  "venue": "Journal of Experimental and Clinical Cancer Research",
  "versions": []
}