{
  "abstract": "Acute respiratory distress syndrome (ARDS) is a highly heterogeneous critical illness syndrome lacking effective targeted therapies, partly due to the diverse patient population. Subphenotype research aims to identify homogeneous patient subgroups sharing common biological, physiological, or clinical characteristics, enabling prognostic and predictive enrichment. This review systematically summarizes current ARDS subphenotype research, from pathobiological mechanisms to multidimensional identification based on etiology, imaging, biomarkers, respiratory mechanics, and transcriptomics. We highlight evidence for differential prognoses and treatment responses across subphenotypes, including variable effects of neuromuscular blockade, corticosteroids, and prone positioning. We further discuss challenges and future directions in translating subphenotype classification into bedside practice. This article provides a theoretical framework and practical guidance for advancing precision medicine in ARDS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory and Critical Care Medicine, Tangdu Hospital, The Fourth Military Medical University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Han Shao"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingting Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Tongtong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanyan Qiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanyan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d9e3bvnj2hx2f.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1947054",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727492/?tool=EBI",
  "id": "d9e3bvnj2hx2f",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1947054/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2740|Respiratory Support and Mechanisms"
    ]
  ],
  "openalex": "W7223005802",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1947054/pdf",
  "pmcid": "PMC13727492",
  "pmid": "42978719",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/d9e3bvnj2hx2f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1947054",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1947054/full"
    },
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13727492",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727492"
    },
    {
      "first_seen": "2026-11-06T12:23:21Z",
      "native_id": "PMC13727492",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphar.2026.1947054"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1663-9812",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Acute respiratory distress syndrome subphenotypes: the translational path from pathobiology to precision medicine",
  "title_text": "Acute respiratory distress syndrome subphenotypes: the translational path from pathobiology to precision medicine",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:40Z",
  "url": "https://research.draconitic.com/paper/d9e3bvnj2hx2f",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}