{
  "abstract": "Pancreatic cancer mortality is primarily driven by metastatic disease, and epithelial-mesenchymal transition (EMT) is one mechanism that promotes this process. The chemokine receptor CXCR2 has been implicated in tumor progression, but its role in pancreatic cancer remains unclear. We investigated CXCR2 in HPAF-II (epithelial-like) and PANC-1 (mesenchymal-like) pancreatic cancer cells. siRNA-mediated CXCR2 knockdown reduced ERK and AKT phosphorylation and decreased PI3K subunit expression in PANC-1 cells, but not HPAF-II cells. Furthermore, CXCR2 knockdown significantly reduced wound closure in PANC-1 cells. These findings indicate that CXCR2 may regulate EMT-associated signaling and migration in mesenchymal-like pancreatic cancer cells.",
  "abstract_shown": true,
  "affiliations": [
    "Biology, University of Saint Joseph"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jacob Krzeminski"
    },
    {
      "affs": [
        0
      ],
      "name": "Irene K. Guttilla Reed"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d9ev7asnf0j9r.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002330",
  "fulltext_url": "https://www.micropublication.org/journals/biology/micropub-biology-002330",
  "id": "d9ev7asnf0j9r",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://doi.org/10.17912/micropub.biology.002330",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "2730|Chemokine receptors and signaling"
    ]
  ],
  "openalex": "W7214118383",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Caltech Library",
  "ris": "https://research.draconitic.com/paper/d9ev7asnf0j9r.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T14:21:02Z",
      "native_id": "10b7c2afc3a04f5d8988822daf291516",
      "source": "doaj",
      "url": "https://doi.org/10.17912/micropub.biology.002330"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Chemokine receptors and signaling",
      "subfield": "oncology"
    }
  ],
  "title": "CXCR2 knockdown reduces ERK and AKT signaling and migration in PANC-1 pancreatic cancer cells",
  "title_text": "CXCR2 knockdown reduces ERK and AKT signaling and migration in PANC-1 pancreatic cancer cells",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T14:20:48Z",
  "url": "https://research.draconitic.com/paper/d9ev7asnf0j9r",
  "venue": "microPublication Biology",
  "versions": []
}