{
  "abstract": "Lazertinib (LECLAZA®) is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor used to treat non-small cell lung cancer (NSCLC), especially in patients with brain metastases. While common adverse events such as rash and pruritus have been reported, voice-related complications and structural laryngeal lesions have not previously been reported. Here, we describe four NSCLC patients who developed new-onset voice changes or globus sensation during lazertinib-based therapy. Laryngoscopic examination revealed multifocal, broad-based polypoid mucosal thickening that was atypical for benign conditions such as contact granuloma or reflux-related disease. Histopathology in one patient demonstrated benign inflamed granulation tissue, and all lesions remained stable without interval progression over 15–36 months of follow-up. Given the small number of cases and the potential confounders, a causal association with lazertinib cannot be established. However, awareness of these benign-appearing mucosal findings may help clinicians avoid unnecessary biopsy or interruption of cancer treatment when evaluating throat or voice symptoms in patients receiving lazertinib therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea .",
    "Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea .",
    "Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea .",
    "Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea ."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Seung Heon Kang",
      "orcid": "0000-0001-6569-825X"
    },
    {
      "affs": [
        2
      ],
      "name": "Hyojin Kim",
      "orcid": "0000-0001-9201-8328"
    },
    {
      "affs": [
        3
      ],
      "name": "Jeong-Yeon Ji",
      "orcid": "0000-0002-7070-8560"
    },
    {
      "affs": [
        3
      ],
      "name": "Woo-Jin Jeong",
      "orcid": "0000-0001-8577-6964"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d9q41zk9f5dnq.bib",
  "cited_by": 0,
  "doi": "10.3346/jkms.2026.41.e340",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13713156/",
  "id": "d9q41zk9f5dnq",
  "issns": [
    "1011-8934",
    "1598-6357"
  ],
  "landing_url": "https://doi.org/10.3346/jkms.2026.41.e340",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Communication"
    ],
    [
      "heading",
      "Oncology & Hematology"
    ],
    [
      "openalex",
      "2740|Lung Cancer Treatments and Mutations"
    ]
  ],
  "openalex": "W7221797875",
  "pdf_url": null,
  "pmcid": "PMC13713156",
  "pmid": "42936980",
  "published": "2026-10-14",
  "publisher": "Korean Academy of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/d9q41zk9f5dnq.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:33Z",
      "native_id": "PMC13713156",
      "source": "pmc",
      "url": "https://doi.org/10.3346/jkms.2026.41.e340"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Lung Cancer Treatments and Mutations",
      "subfield": "general"
    }
  ],
  "title": "Previously Unrecognized Distinct Laryngeal Lesions During Lazertinib Therapy in EGFR-Mutated NSCLC: A Case Series",
  "title_text": "Previously Unrecognized Distinct Laryngeal Lesions During Lazertinib Therapy in EGFR-Mutated NSCLC: A Case Series",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:33Z",
  "url": "https://research.draconitic.com/paper/d9q41zk9f5dnq",
  "venue": "Journal of Korean Medical Science",
  "versions": []
}