{
  "abstract": "Aim\n\nPoisoning-related out-of-hospital cardiac arrest (OHCA) may have distinct age-specific trends. We examined temporal changes in its proportion among all OHCA, population-based incidence, and neurological outcomes in Japan.Methods\n\nIn this retrospective nationwide registry study, we analyzed adults aged ≥18 years OHCA treated by emergency medical services (EMS) in the Japanese Utstein registry from 2013 to 2023. Age-specific logistic regression estimated annual trends in the proportion of poisoning-related OHCA, adjusted for age and sex. Poisson regression with age-group population as the exposure estimated incidence trends. Neurological outcome trends were examined secondarily.Results\n\nAmong 1,400,951 adults with OHCA treated by EMS, 3723 (0.27%) had poisoning-related OHCA. In adults aged 18-29 years, the adjusted odds of poisoning-related OHCA increased (odds ratio per year, 1.027; 95% CI, 1.001-1.054), whereas population-based incidence showed a nonsignificant upward trend (incidence rate ratio, 1.020; 95% CI, 0.995-1.046). All-cause OHCA incidence declined among adults aged 18-29 years (incidence rate ratio, 0.991; 95% CI, 0.983-0.9997). The poisoning proportion decreased at ages 50-64 and ≥65 years; poisoning incidence declined significantly only at ≥65 years. Favorable neurological outcome after poisoning-related OHCA showed no clear improvement (adjusted odds ratio per year, 0.998; 95% CI, 0.949-1.050).Conclusion\n\nPoisoning-related OHCA became increasingly prominent among young adults but declined among older adults. Although the incidence increase in young adults was not statistically significant, its upward direction, declining all-cause OHCA incidence, and lack of clear neurological outcome improvement suggest increasing clinical importance of poisoning-related OHCA in young adults.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Toxicology, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Takuyo Chiba",
      "orcid": "0000-0002-8189-5461"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryoko Kyan"
    },
    {
      "affs": [
        0
      ],
      "name": "Michiko Takai"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomohisa Nagayama"
    },
    {
      "affs": [
        0
      ],
      "name": "Kurumi Mori"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshito Kamijo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/d9ttsearrv34g.bib",
  "cited_by": 0,
  "doi": "10.1016/j.resplu.2026.101522",
  "fulltext_url": "https://europepmc.org/articles/PMC13694750",
  "id": "d9ttsearrv34g",
  "issns": [
    "2666-5204"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927144",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2711|Cardiac Arrest and Resuscitation"
    ]
  ],
  "openalex": "W7220689184",
  "pdf_url": "https://europepmc.org/articles/PMC13694750?pdf=render",
  "pmcid": "PMC13694750",
  "pmid": "42927144",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/d9ttsearrv34g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927144",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927144"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2711|Cardiac Arrest and Resuscitation",
      "subfield": "general"
    }
  ],
  "title": "Age-specific trends in poisoning-related out-of-hospital cardiac arrest in Japan: a retrospective nationwide registry study.",
  "title_text": "Age-specific trends in poisoning-related out-of-hospital cardiac arrest in Japan: a retrospective nationwide registry study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/d9ttsearrv34g",
  "venue": "Resuscitation plus",
  "versions": []
}