{
  "abstract": "Background: Inflammatory bowel disease (IBD) is characterized by chronic inflammation intertwined with fibrosis and increased necroptosis. Vimentin, an intermediate filament protein closely associated with fibrosis and several inflammatory pathways, is elevated in IBD tissues. We conducted experiments to determine the effect of neutralization of extracellular vimentin with an anti-vimentin antibody (Ab) on the pathogenesis of IBD. Methods: IBD was mimicked in a 7-week C57BL6 mice by mixing 3% dextran sodium sulfate (DSS) in autoclaved drinking water for five days. Anti-vimentin Ab was intraperitoneally injected with a concentration of 3 milligrams per kilogram repeatedly in a three-day interval simultaneously with DSS administration. Results: In dextran sodium sulfate (DSS)-induced colitis mice, the anti-vimentin Ab decreased the levels of total and cell-surface vimentin in colon tissues compared to control-treated mice. In DSS-induced colitis mice, treatment with the anti-vimentin Ab improved body weight loss and colon shortening, thereby reducing the severity of DSS-induced colitis. In addition, the anti-vimentin Ab reduced the number of cells expressing fibrosis markers, inflammatory cytokines, and necroptotic markers in colon tissues of DSS-induced colitis mice. In CCD-18CO human colon epithelial cells, the increases in the levels of fibrosis markers caused by TGFβ were enhanced by vimentin protein stimulation and the anti-vimentin Ab reduced the levels of fibrosis-related factors. Conclusion: This is the first report of the therapeutic effect of an anti-vimentin Ab on the pathogenic mechanisms of IBD. Further studies are needed to confirm its therapeutic potential in clinical settings.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.",
    "Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.",
    "Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.",
    "Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.",
    "Mitochondrial Immunomedicine Center for Global Health Therapeutics (MIGHT), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sol Kim"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Hye Yeon Kang"
    },
    {
      "affs": [
        1,
        3,
        4
      ],
      "name": "Jin-Sil Park"
    },
    {
      "affs": [
        1,
        3,
        4
      ],
      "name": "JeongWon Choi"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Ha Yeon Jeong"
    },
    {
      "affs": [
        1,
        3,
        4
      ],
      "name": "Seon Yeong Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Hee Lee",
      "orcid": "0000-0002-8244-374X"
    },
    {
      "affs": [
        0
      ],
      "name": "Bo-In Lee",
      "orcid": "0000-0002-0218-4136"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Mi-La Cho",
      "orcid": "0000-0001-5715-3989"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/da5rcw2apybbz.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0352641",
  "fulltext_url": "https://europepmc.org/articles/PMC13682657",
  "id": "da5rcw2apybbz",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0352641",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Digestive system/Gastrointestinal tract/Colon"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Glycobiology/Polysaccharides/Glucans/Dextran"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Cytoskeletal proteins/Vimentin"
    ],
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      "/Biology and life sciences/Developmental biology/Fibrosis"
    ],
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      "plos",
      "/Biology and life sciences/Immunology/Immune response/Inflammation"
    ],
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      "plos",
      "/Medicine and health sciences/Anatomy/Digestive system/Gastrointestinal tract/Colon"
    ],
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      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Gastroenterology and hepatology/Inflammatory bowel disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Gastroenterology and hepatology/Inflammatory bowel disease/Colitis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune response/Inflammation"
    ],
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      "plos",
      "/Research and analysis methods/Model organisms/Mouse models"
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  "openalex": "W7223061230",
  "pdf_url": "https://europepmc.org/articles/PMC13682657?pdf=render",
  "pmcid": "PMC13682657",
  "pmid": "42900677",
  "published": "2026-10-20",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/da5rcw2apybbz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:23Z",
      "native_id": "10.1371/journal.pone.0352641",
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      "url": "https://doi.org/10.1371/journal.pone.0352641"
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:developmental biology",
      "subfield": "developmental-biology"
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    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
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    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
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  "title": "Vimentin neutralizing antibody ameliorate inflammatory bowel disease by inhibiting fibrosis and inflammatory cell death",
  "title_text": "Vimentin neutralizing antibody ameliorate inflammatory bowel disease by inhibiting fibrosis and inflammatory cell death",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/da5rcw2apybbz",
  "venue": "PLOS One",
  "versions": []
}