{
  "abstract": "Background/purpose\n\nDrug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.Materials and methods\n\nA comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional enrichment and canonical pathway analysis via Ingenuity Pathway Analysis (IPA).Results\n\nBibliometric mapping revealed a significant shift from basic cell-intrinsic molecules toward complex themes, including tumor microenvironment (TME), intercellular communications, cancer stem cells (CSCs), and non-coding RNA networks. Frequency distribution analysis identified microRNA as the most prevalent mediator, highlighting the principal role of post-transcriptional regulation. Furthermore, CSCs and epithelial-mesenchymal transition (EMT) emerged as major thematic hubs within the co-occurrence network. GeneCards analysis identified ABCB1, ABCG2, EGFR, and STAT3 as central hubs with high relevance scores. IPA further validated these findings, demonstrating dense crosstalk between TME and EMT-related pathways as the mechanistic foundation of therapeutic escape.Conclusion\n\nThe study demonstrated oral cancer resistance is governed by signaling redundancy and microenvironmental protection rather than an individual biological aberration. Consequently, future researches are needed to investigate intercellular crosstalk and cellular heterogeneity in oral cancer to circumvent the multifaceted barriers driving current therapeutic failure.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate Institute of Medical Sciences, National Defense Medical University, Taipei, Taiwan.",
    "Molecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Science, National Defense Medical University, Taipei, Taiwan.",
    "Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.",
    "Department of Risk Management and Insurance, National Chengchi University, Taipei, Taiwan.",
    "Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.",
    "Department of Dentistry, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chu-Yen Chien"
    },
    {
      "affs": [
        1
      ],
      "name": "Ying-Chen Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Jia-Rong Wu"
    },
    {
      "affs": [
        3
      ],
      "name": "Hsu-Hua Chu"
    },
    {
      "affs": [
        4
      ],
      "name": "Yi-Jen Hung"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Yi-Shing Shieh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/da79k7za4brxz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jds.2025.07.3587",
  "fulltext_url": "https://europepmc.org/articles/PMC13689595",
  "id": "da79k7za4brxz",
  "issns": [
    "1991-7902",
    "2213-8862"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924173",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7223566219",
  "pdf_url": "https://europepmc.org/articles/PMC13689595?pdf=render",
  "pmcid": "PMC13689595",
  "pmid": "42924173",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/da79k7za4brxz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42924173",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924173"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "A bibliometric evolution of molecular mechanisms and emerging research trends of therapeutic resistance in oral cancer.",
  "title_text": "A bibliometric evolution of molecular mechanisms and emerging research trends of therapeutic resistance in oral cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/da79k7za4brxz",
  "venue": "Journal of dental sciences",
  "versions": []
}