{
  "abstract": "BACKGROUND: Atriogenic tethering (AT) is a characteristic feature of the mitral valve in atrial functional mitral regurgitation (AFMR). However, the factors associated with AT are not well known. METHODS AND RESULTS: This was a post hoc analysis of REVEAL-AFMR, a retrospective observational study involving patients with moderate or greater AFMR. A stepwise binary logistic regression model was used to identify factors associated with AT. The primary endpoint was a composite of cardiovascular death, heart failure hospitalization, and mitral valve intervention. Of 1,007 patients, 245 (24%) had AT and 762 (76%) did not. Of 15 clinical variables related to AT in AFMR, greater left ventricular end-systolic dimension and left atrial diameter were independently associated with AT. The 3-year rate of freedom from the primary outcome was significantly lower in the group with than without AT (63.2% vs. 71.2%; P=0.002). The risk of the primary outcome was significantly higher in the group with than without AT (adjusted hazard ratio 1.34; 95% confidence interval 1.04-1.74; P=0.026), although the results were inconsistent in the sensitivity analysis using propensity score overlap weighting. CONCLUSIONS: AT was identified in 24% of patients with moderate or greater AFMR. Greater left ventricular end-systolic and left atrial anteroposterior dimensions were factors associated with AT. Among patients with AFMR, those with AT showed a poor prognosis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Nami Omori"
    },
    {
      "name": "Masashi Amano"
    },
    {
      "name": "Tomohiro Kaneko"
    },
    {
      "name": "Yukio Sato"
    },
    {
      "name": "Yohei Ohno"
    },
    {
      "name": "Masaru Obokata"
    },
    {
      "name": "Kimi Sato"
    },
    {
      "name": "Taiji Okada"
    },
    {
      "name": "Kojiro Morita"
    },
    {
      "name": "Tomoko Machino-Ohtsuka"
    },
    {
      "name": "Yukio Abe"
    },
    {
      "name": "Chisato Izumi"
    },
    {
      "name": "Nobuyuki Kagiyama"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/daa8484mtqz0n.bib",
  "cited_by": 3,
  "doi": "10.1253/circj.cj-25-0465",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0465/_article",
  "id": "daa8484mtqz0n",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0465/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W4414273310",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-25-0465/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/daa8484mtqz0n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-0465",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0465/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Factors Associated With and Prognosis of Atriogenic Tethering in Patients With Atrial Functional Mitral Regurgitation",
  "title_text": "Factors Associated With and Prognosis of Atriogenic Tethering in Patients With Atrial Functional Mitral Regurgitation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/daa8484mtqz0n",
  "venue": "Circulation Journal",
  "versions": []
}