{
  "abstract": "A 59-year-old man presented with fever, erythema multiforme, and pancreatic swelling. Laboratory tests revealed severe peripheral hypereosinophilia without a history of relevant medication or evidence of infection. Bone marrow analysis revealed no blast proliferation or leukemia-associated fusion genes. Notably, Wilms' tumor gene (WT1) mRNA was markedly elevated at 26,000 copies/µg RNA. Idiopathic hypereosinophilic syndrome was diagnosed, and oral corticosteroid therapy was initiated, resulting in rapid and complete improvement. This case highlights a rare presentation of idiopathic hypereosinophilic syndrome with high WT1 mRNA, which helps in the differential diagnosis between secondary (reactive) and idiopathic hypereosinophilic syndrome (HES).",
  "abstract_shown": true,
  "affiliations": [
    "Gastroenterology, JR Sendai Hospital, Sendai, JPN.",
    "Internal Medicine, JR Sendai Hospital, Sendai, JPN.",
    "Dermatology, JR Sendai Hospital, Sendai, JPN."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Keiichi Tamai"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuzo Suzuki"
    },
    {
      "affs": [
        2
      ],
      "name": "Teie Egawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Hiroki Kikuchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Shiho Uchiyama"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryosuke Kikuchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Hiroshi Yokoyama"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dac2wjy1c8620.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116864",
  "fulltext_url": "https://europepmc.org/articles/PMC13695551",
  "id": "dac2wjy1c8620",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927137",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Eosinophilic Disorders and Syndromes"
    ]
  ],
  "openalex": "W7214211601",
  "pdf_url": "https://europepmc.org/articles/PMC13695551?pdf=render",
  "pmcid": "PMC13695551",
  "pmid": "42927137",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dac2wjy1c8620.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927137",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927137"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Eosinophilic Disorders and Syndromes",
      "subfield": "general"
    }
  ],
  "title": "A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA.",
  "title_text": "A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/dac2wjy1c8620",
  "venue": "Cureus",
  "versions": []
}