{
  "abstract": "Introduction: Recombinant Adeno-Associated Vectors (AAV) represent nowadays the most largely used platform for in vivo gene therapy. Unfortunately, despite promising results in preclinical and clinical studies, pre-existing immunity against the viral capsid remains one of the major hurdles to the safety and efficiency of AAV-based gene transfer in Humans. Particularly, the impact of pre-existing anti-AAV CD8+ T lymphocytes on gene transfer remains poorly defined. This gap in knowledge can, in part, be attributed to the scarcity of AAV-specific CD8+ T cells among the peripheral blood mononuclear cells (PBMCs), and to the lack of relevant animal models. Experimental approach: In order to set up a more sensitive and comprehensive method to detect and characterise AAV-specific CD8+ T cells among PBMCs, we used Tetramer-Associated Magnetic Enrichment (TAME) to analyse the frequency and phenotype of AAV-specific CD8+ T cells by flow cytometry. To this end, we previously generated AAV-loaded tetramers using the UV-mediated peptide exchange technology.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Celine Vandamme"
    },
    {
      "name": "Marie Devaux"
    },
    {
      "name": "Nicolas Jaulin"
    },
    {
      "name": "Mickaël Guilbaud"
    },
    {
      "name": "Johanne Le Duff"
    },
    {
      "name": "Leslie Hesnard"
    },
    {
      "name": "Hanane Djamai"
    },
    {
      "name": "Marc Bonneville"
    },
    {
      "name": "Philippe Moullier"
    },
    {
      "name": "Xavier Saulquin"
    },
    {
      "name": "Oumeya Adjali"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dapjfm8293hwm.bib",
  "cited_by": 1,
  "doi": "10.1016/s1525-0016(16)33505-5",
  "fulltext_url": null,
  "id": "dapjfm8293hwm",
  "issns": [
    "1525-0016",
    "1525-0024"
  ],
  "landing_url": "https://nantes-universite.hal.science/hal-05742551v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Virus-based gene therapy research"
    ]
  ],
  "openalex": "W2565507938",
  "pdf_url": "https://nantes-universite.hal.science/hal-05742551/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/dapjfm8293hwm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "hal-05742551",
      "source": "hal",
      "url": "https://nantes-universite.hal.science/hal-05742551v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Virus-based gene therapy research",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "An AAV8 Mutant with Better Transduction in Murine Muscle and Nasal Airway Than AAV8",
  "title_text": "An AAV8 Mutant with Better Transduction in Murine Muscle and Nasal Airway Than AAV8",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/dapjfm8293hwm",
  "venue": "Molecular Therapy",
  "versions": []
}