{
  "abstract": "Background: Persistent respiratory and functional impairments after pulmonary tuberculosis can reduce exercise capacity and health-related quality of life. This systematic review and meta-analysis evaluated structured rehabilitation in adults with post-tuberculosis lung disease (PTLD). Methods: The review followed PRISMA 2020 and was prospectively registered in PROSPERO (CRD420261338253). PubMed/MEDLINE, Scopus, Web of Science Core Collection, CENTRAL, and PEDro were searched from inception, with final bibliographic updating through 5 September 2026 and trial registry cross-linking through 28 August 2026. Results: Seven randomized trial reports were included. Two directly comparable adjusted ISWT trials are presented as the main exercise capacity findings: a study published in 2026 reported +54.36 m (95% CI 17.22 to 91.51) and a research conducted in 2026 reported +123.0 m (95% CI 81.1 to 164.8). The pooled random-effects estimate was +87.98 m (95% Hartung–Knapp CI −348.01 to 523.96), but this estimate is presented secondarily because the interval was extremely wide with only two contributing trials. A 120-participant RCT reported an adjusted 6MWD benefit of +87.4 m (95% CI 74.2 to 100.6). A newly identified three-arm RCT (n = 180) reported statistically significant omnibus between-group differences, but substantial baseline imbalance and unusual control group reporting patterns limit device-versus-control interpretation. Certainty was very low for exercise capacity, dyspnea, health-related quality of life, pulmonary function, inspiratory muscle strength, and adverse events. Conclusions: Accordingly, the evidence is very uncertain regarding the effects of structured rehabilitation on these outcomes and regarding the magnitude and generalizability of any benefit in PTLD.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Internal Medicine—Department of Pulmonology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Department of Physiotherapy, Faculty of Nursing, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania",
    "Department of Medical Informatics and Biostatistics, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marin Vlăduț Piciorea",
      "orcid": "0009-0003-0265-9730"
    },
    {
      "affs": [
        1
      ],
      "name": "Gabriela-Marina Andrei"
    },
    {
      "affs": [
        1
      ],
      "name": "Mihai Olteanu",
      "orcid": "0000-0002-3338-8107"
    },
    {
      "affs": [
        2
      ],
      "name": "Daniela Matei",
      "orcid": "0000-0002-5681-8237"
    },
    {
      "affs": [
        3
      ],
      "name": "Mihaela Ionescu"
    },
    {
      "affs": [
        2
      ],
      "name": "Magdalena Rodica Trăistaru",
      "orcid": "0000-0002-6555-5731"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/db29wjq3m6tbz.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218397",
  "fulltext_url": null,
  "id": "db29wjq3m6tbz",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8397",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Tuberculosis Research and Epidemiology"
    ]
  ],
  "openalex": "W7224092259",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/db29wjq3m6tbz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218397",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8397"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Tuberculosis Research and Epidemiology",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Comparative Effectiveness of Rehabilitation Programs for Adults with Post-Tuberculosis Lung Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials",
  "title_text": "Comparative Effectiveness of Rehabilitation Programs for Adults with Post-Tuberculosis Lung Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/db29wjq3m6tbz",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}