{
  "abstract": "Purpose\n\nTo investigate the association between age at type 2 diabetes mellitus (T2DM) onset and the risk of Irvine-Gass Syndrome (IGS) following uneventful phacoemulsification with intraocular lens implantation (PEI).Methods\n\nThis retrospective case-control study analyzed 190 participants (39 IGS, 151 non-IGS) who underwent uneventful PEI. Comprehensive demographic, systemic, and perioperative data were collected. Statistical analyses included between-group comparisons, logistic regression, and Receiver Operating Characteristic (ROC) curve analysis to identify independent IGS predictors and determine optimal risk-stratification thresholds.Results\n\nWhile overall T2DM prevalence was comparable between groups (p = 0.168), IGS patients had significantly earlier diabetes onset (49.05±8.61 vs. 59.23±10.65 years, p < 0.001). Multivariable analysis confirmed younger T2DM onset age as an independent IGS predictor (OR = 1.094 per year decrease, 95% Confidence Interval [95% CI 1.015‒1.179], p = 0.019). ROC analysis identified T2DM onset age ≤ 55.5-years as the optimal predictive threshold (Area Under the ROC Curve [AUROC = 0.774], sensitivity = 73.7%, specificity = 78.9%). Participants stratified by this threshold showed significantly different IGS incidence (non-diabetic: 15.32%; younger-onset T2DM: 56.67%; older-onset T2DM: 10.20%; p < 0.001). Younger-onset T2DM patients had approximately 5.5-fold higher IGS odds versus non-diabetics (adjusted OR = 5.499, 95% CI 2.104‒14.373, p = 0.001).Conclusions\n\nEarlier T2DM onset (≤ 55.5-years) is a strong independent risk factor for IGS following uneventful PEI. This threshold provides a clinically useful tool for preoperative risk stratification, particularly valuable for identifying high-risk diabetic patients who may benefit from enhanced perioperative monitoring and management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Beijing Geriatric Hospital, Beijing, China.",
    "Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua Medicine, Tsinghua University, Beijing, China.",
    "Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua Medicine, Tsinghua University, Beijing, China. Electronic address: sishancheng@126.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yingxia Yin"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Junyi Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Wan Lu"
    },
    {
      "affs": [
        2
      ],
      "name": "Shancheng Si"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/db7rg87njejhv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.clinsp.2026.101204",
  "fulltext_url": "https://europepmc.org/articles/PMC13693337",
  "id": "db7rg87njejhv",
  "issns": [
    "1807-5932",
    "1980-5322"
  ],
  "landing_url": "https://europepmc.org/article/MED/42874505",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Retinal Diseases and Treatments"
    ]
  ],
  "openalex": "W7221831159",
  "pdf_url": "https://europepmc.org/articles/PMC13693337?pdf=render",
  "pmcid": "PMC13693337",
  "pmid": "42874505",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/db7rg87njejhv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42874505",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42874505"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Retinal Diseases and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome.",
  "title_text": "Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/db7rg87njejhv",
  "venue": "Clinics (Sao Paulo, Brazil)",
  "versions": []
}