{
  "abstract": "Dengvaxia ® induces antibody responses in dengue virus (DENV)-naïve children, but the durability of these responses and their impact on subsequent wild-type (WT) DENV infection remain unclear. Although previous studies have primarily evaluated vaccine efficacy against dengue disease, the impact of Dengvaxia ® on susceptibility to WT DENV infection and subsequent immune responses remains less well defined. We evaluated vaccine-induced immunity and susceptibility to WT DENV infection in a longitudinal cohort of 186 seronegative children, including 114 who received a single dose of Dengvaxia ® and 72 who remained unvaccinated, followed for 40 months. Samples collected at baseline and two follow-up time points (20 months [T1] and 40 months [T2]) were analyzed using yellow fever virus (YFV) non-structural protein 1 (NS1) antibody assays, which is expressed by Dengvaxia ® but not by WT DENV, enabling discrimination between vaccine-associated and WT infection-induced responses. At T1, 61% of vaccinated children were responders. Additional low-level YFV NS1 antibody responses were detected in some children originally classified as vaccine non-responders, suggesting that the predefined binary classification may not capture the full range of vaccine-associated antibody responses. Low-level YFV NS1 responses remained detectable through T2. During the first follow-up period (baseline-T1), vaccination was associated with a reduced risk of WT DENV infection (vaccine effectiveness [VE]=45%). During the second period (T1-T2), no difference in infection risk was detected between groups. Following breakthrough infection during the first follow-up period, vaccinated children developed antibody responses with greater magnitude and broader serotype breadth than unvaccinated children with primary infection, consistent with vaccine-associated immune priming following WT DENV infection. In contrast, during the second period (T1-T2), differences in antibody magnitude and breadth following infection were no longer detected between groups. Together, these findings suggest that a single dose of Dengvaxia ® in DENV-seronegative children was associated with a reduced risk of WT DENV infection and with differences in subsequent antibody responses during the first follow-up period, but these associations were no longer observed during the second period.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology and Immunology, University of North Carolina",
    "Institute of Child Health and Human Development, University of the Philippines Manila"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maria Abad Fernandez"
    },
    {
      "affs": [
        1
      ],
      "name": "Jedas Veronica Daag"
    },
    {
      "affs": [
        0
      ],
      "name": "Lindsay D. Hein"
    },
    {
      "affs": [
        1
      ],
      "name": "Kristal An Agrupis"
    },
    {
      "affs": [
        1
      ],
      "name": "Maria Vinna Crisostomo"
    },
    {
      "affs": [
        1
      ],
      "name": "Michelle Ylade"
    },
    {
      "affs": [
        1
      ],
      "name": "Jacqueline Deen"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura J. White"
    },
    {
      "affs": [
        0
      ],
      "name": "Lakshmanane Premkumar"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana Lena Lopez"
    },
    {
      "affs": [
        0
      ],
      "name": "Aravinda M. de Silva"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/db7y0n79rs7ad.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1959704",
  "fulltext_url": "https://europepmc.org/articles/PMC13713805",
  "id": "db7y0n79rs7ad",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1959704/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7221757453",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1959704/pdf",
  "pmcid": "PMC13713805",
  "pmid": "42952807",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/db7y0n79rs7ad.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1959704",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1959704/full"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952807",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952807"
    },
    {
      "first_seen": "2026-11-01T12:21:25Z",
      "native_id": "PMC13713805",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1959704"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "A single dose of Dengvaxia is associated with transient reduction in dengue infection risk among dengue-naïve children",
  "title_text": "A single dose of Dengvaxia is associated with transient reduction in dengue infection risk among dengue-naïve children",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:25Z",
  "url": "https://research.draconitic.com/paper/db7y0n79rs7ad",
  "venue": "Frontiers in Immunology",
  "versions": []
}